Histamine or adenosine blockade alters intestinal blood flow autoregulation in swine.
Histamine or adenosine blockade alters intestinal blood flow autoregulation in swine.
复制标题
组胺或腺苷阻断改变猪肠道血流的自动调节。
DOI：
10.1152/ajpgi.1988.254.2.g156
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Owusu,K
中科院分区：
文献类型：
--
作者：
Buckley,NM;Diamant,S;Frasier,ID;Owusu,K
在戊巴比妥钠(30 mg/kg)麻醉下，观察两组禁食动物组胺H1或腺苷受体阻断前和阻断期间的压力-流量关系，探讨组胺或腺苷在1月龄猪肠道血流自动调节中的可能作用。记录腹主动脉和胸主动脉压力以及肠系膜上动脉和左肾动脉血流在腹主动脉腹主动脉上方受控加压期间的变化。在获得对照的肠和肾压力-流量关系后，将测试剂量的激动剂(组胺0.1微克或腺苷0.2微克/千克体重)注入肠系膜上动脉。然后开始动脉内输注阻滞剂(0.1 mg·kg~(-1)·min~(-1)扑尔敏或10摩尔/分钟茶碱)。在获得第二组肠和肾压力-流量关系之前和之后，通过给予激动剂的剂量来评估阻断程度。氯苯那敏完全阻断肠道血管组胺H1受体，茶碱减弱腺苷受体不完全阻断，肠血流自动调节。肾血流自动调节维持在正常水平。这些结果表明，组胺和腺苷都是在幼猪动脉压降低时参与肠道血流自动调节的生理血管扩张剂。
The possible role of histamine or adenosine in intestinal blood flow autoregulation in 1-mo-old swine was examined by obtaining pressure-flow relationships before and during intestinal histamine H1- or adenosine-receptor blockade in two groups of fasting animals under anesthesia with pentobarbital sodium (30 mg/kg). Changes in abdominal and thoracic aortic pressures and in superior mesenteric and left renal arterial flows were recorded during controlled aortic compression above the celiac artery. After control intestinal and renal pressure-flow relationships were obtained, a test dose of agonist (0.1 microgram histamine or 0.2 microgram adenosine/kg body wt) was given into the superior mesenteric artery. Then an intra-arterial infusion of blocking agent was started (0.1 mg.kg-1.min-1 chlorpheniramine or 10 mumol/min theophylline). Degree of blockade was assessed with doses of agonist given before and after a second set of intestinal and renal pressure-flow relationships was obtained. Complete blockade of intestinal vascular histamine H1-receptors with chlorpheniramine abolished, and incomplete blockade of adenosine-receptors with theophylline attenuated, intestinal blood flow autoregulation. Renal blood flow autoregulation remained at its control level. These results indicate that both histamine and adenosine are among the physiological vasodilators contributing to intestinal blood flow autoregulation when arterial pressure is decreased in young swine.