TUMOR-ASSOCIATED ISOENZYMES OF GAMMA-GLUTAMYL-TRANSFERASE TRANSFERASE IN THE SERUM OF PATIENTS WITH HEPATOCELLULAR-CARCINOMA
TUMOR-ASSOCIATED ISOENZYMES OF GAMMA-GLUTAMYL-TRANSFERASE TRANSFERASE IN THE SERUM OF PATIENTS WITH HEPATOCELLULAR-CARCINOMA
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DOI：
10.1038/bjc.1984.200
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发表时间：
1984-01-01
影响因子：
8.8
通讯作者：
ROWE, P
中科院分区：
文献类型：
--
作者：
KEW, MC;WOLF, P;ROWE, P
Sera from 391 southern African Blacks with hepatocellular carcinoma, matched controls, patients with other malignant tumors, and with various forms of hepatobiliary disease were fractionated by polyacrylamide gradient gel electrophoresis to determine the prevalence of tumor-associated .gamma.-glutamyl transferase isoenzymes in Black patients with hepatocellular carcinoma. One or more tumor-associated isoenzymes (I'', I'''' or II'') were present in 58.6% of the patients with hepatocellular carcinoma: I'' in 54.5%, I'''' in 27.1%, and II'' in 34%. These isoenzymes were detected in 1 patient with prostatic cancer, occasionally in patients with acute viral hepatitis, but in no normal individuals. The presence of tumor-associated isoenzymes was not related to patient age, sex or hepatitis-B virus status or to the tumor burden. Isoenzymes were present in 42% of hepatocellular carcinoma patients with a normal serum .alpha.-fetoprotein concentration and in 50% of those with a nondiagnostic value. .gamma.-Glutamyl transferase isoenzymes may be supplementary to .alpha.-fetoprotein in the diagnosis of hepatocellular carcinoma.
