Recombinant Canine Coronaviruses Related to Transmissible Gastroenteritis Virus of Swine Are Circulating in Dogs
Recombinant Canine Coronaviruses Related to Transmissible Gastroenteritis Virus of Swine Are Circulating in Dogs
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DOI：
10.1128/jvi.01937-08
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发表时间：
2009-02-01
影响因子：
5.4
通讯作者：
Buonavoglia, Canio
中科院分区：
文献类型：
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作者：
Decaro, Nicola;Mari, Viviana;Buonavoglia, Canio
在死于急性胃肠炎的幼犬的肠道和内脏器官中发现了四种犬类冠状病毒 II 型 (CCoV-II) 毒株。 CCoV-II 毒株在刺突蛋白的 N 末端结构域与猪传染性胃肠炎病毒 (TGEV) 严格相关，而在基因组的其他部分，观察到与最近的 CCoV-II 分离株具有更高的遗传相关性。犬实验性感染 TGEV 样分离株可诱发轻度胃肠炎，但没有任何全身性受累。通过病毒中和测试，发现了参考 CCoV 和 TGEV 样 CCoV 之间的抗原差异。我们的数据支持 TGEV 样 CCoV 的潜在重组起源。
Four canine coronavirus type II (CCoV-II) strains were identified in the guts and internal organs of pups which had died of acute gastroenteritis. The CCoV-II strains were strictly related to porcine transmissible gastroenteritis virus (TGEV) in the N-terminal domain of the spike protein, whereas in the other parts of the genome, a higher genetic relatedness to recent CCoV-II isolates was observed. Experimental infection of dogs with a TGEV-like isolate induced mild gastroenteritis without any systemic involvement. By virus neutralization tests, antigenic differences between reference and TGEV-like CCoVs were found. Our data support the potential recombinant origin of the TGEV-like CCoVs.