Expected contribution to serum oestradiol from individual ovarian follicles in unstimulated cycles
Expected contribution to serum oestradiol from individual ovarian follicles in unstimulated cycles
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DOI：
10.1093/humrep/15.9.1909
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发表时间：
2000-09-01
影响因子：
6.1
通讯作者：
Hull, MGR
中科院分区：
文献类型：
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作者：
Cahill, DJ;Wardle, PG;Hull, MGR
在未刺激的周期中，缺乏血清雌二醇浓度与卵泡大小相关的数据。我们提供了精确的数据，预计血清浓度的任何卵泡直径（FD）在中期至晚期卵泡阶段。本文对35例排卵周期正常的不孕妇女在128个单卵泡周期中进行了详细的研究。用数学模型来解释同一妇女的重复周期，探讨了血清雌二醇与FD的关系，并计算了FD时血清雌二醇的参考范围。LH峰开始时的血清雌二醇浓度[患者数量，几何平均值，95%置信区间（CI）]在“受精”周期中较高（73，1279，1180-1378 pmol/l）与“未受精”周期相比（31，1055，929-1197 pmol/l，P = 0.008）和“无卵”周期（24，1064，922-1227 pmol/l，P = 0.03）。在“受精”周期，雌二醇浓度呈指数上升与FD和每个大小的卵泡的雌二醇分布是偏斜的。功能性卵母细胞能力在正常排卵周期中变化，与排卵前血清雌二醇相关，但与FD无关。在LH峰出现之前，任何给定直径的成熟卵泡的血清雌二醇在很宽的范围内变化。
Data relating serum oestradiol concentration to follicle size in unstimulated cycles are lacking. We provide precise data on serum concentrations expected for any follicle diameter (FD) in the mid- to late follicular phase. Infertile women (n = 35) with apparently normal ovulatory cycles were studied in detail in 128 unstimulated monofollicular cycles leading to IVF, Using mathematical modelling to account for repeated cycles in the same woman, the relationship between serum oestradiol and FD was explored and reference ranges for serum oestradiol at individual FD were calculated. Serum oestradiol concentrations [number of patients, geometric mean, 95% confidence interval (CI)] at the onset of the LH surge were higher in 'fertilized' cycles (73, 1279, 1180-1378 pmol/l) compared with 'unfertilized' cycles (31, 1055, 929-1197 pmol/l, P = 0.008) and 'no oocyte' cycles (24, 1064, 922-1227 pmol/l, P = 0.03) respectively. In 'fertilized' cycles, oestradiol concentrations rose exponentially with FD and for each size of follicle the oestradiol distribution was skewed. Functional oocyte competence varied in apparently normal ovulatory cycles and was correlated with pre-ovulatory serum oestradiol but not FD, Serum oestradiol varies within wide limits for maturing follicles of any given diameter prior to the onset of the LH surge.