Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease.
Comparison of discriminative properties among disease-specific questionnaires for measuring health-related quality of life in patients with chronic obstructive pulmonary disease.
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用于测量慢性阻塞性肺疾病患者健康相关生活质量的疾病特异性问卷的辨别特性比较。
DOI：
10.1097/00008483-199907000-00016
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发表时间：
1998
影响因子：
24.7
通讯作者：
T. Izumi
中科院分区：
文献类型：
--
作者：
T. Hajiro;K. Nishimura;M. Tsukino;A. Ikeda;H. Koyama;T. Izumi
已引入三种疾病特异性健康相关生活质量（HRQL）问卷来评估慢性阻塞性肺疾病（COPD）患者：圣乔治呼吸问卷（SGRQ）、呼吸问题问卷（BPQ）和慢性呼吸疾病问卷（CRQ）。本研究的目的是比较SGRQ，BPQ和CRQ的区分属性，并澄清每个问卷的特点。143例轻度至重度COPD患者完成了肺功能检查、渐进式踏车运动能力测试、呼吸困难、焦虑和抑郁评估以及HRQL评估。问卷得分的频率分布显示，SGRQ和CRQ呈正态分布，BPQ向低得分倾斜。三份问卷的所有维度之间的关系都是显着的（相关系数[Rs] = 0.74至0.86）。三份问卷与一些生理变量（VC、FEV 1和DL（CO）/VA）具有显著但弱的相关性（Rs = -0.24至-0.36），与运动能力和呼吸困难、焦虑和抑郁评估具有轻度至中度相关性。逐步多元回归分析显示，基线呼吸困难指数（BDI）评分、医院焦虑抑郁量表（HAD）焦虑和最大摄氧量（VO 2 max）占SGRQ方差的61%，BDI和HAD焦虑分别占BPQ和CRQ方差的53%和49%。呼吸困难和心理状态影响COPD患者的HRQL。虽然SGRQ，BPQ和CRQ之间没有实质性的差异是明显的生理参数和影响因素的相关性，BPQ被认为是歧视比SGRQ和CRQ在评估HRQL横截面。
Three disease-specific, health-related quality of life (HRQL) questionnaires have been introduced to assess patients with chronic obstructive pulmonary disease (COPD): the St. George's Respiratory Questionnaire (SGRQ), the Breathing Problems Questionnaire (BPQ), and the Chronic Respiratory Disease Questionnaire (CRQ). The purpose of the present study was to make comparisons between the SGRQ, the BPQ, and the CRQ in their discriminative properties, and to clarify the characteristics of each questionnaire. One hundred forty-three patients with mild to severe COPD completed pulmonary function tests, progressive cycle ergometer testing for exercise capacity, assessment of dyspnea, anxiety, and depression, and assessment of HRQL. The frequency distributions of the questionnaire scores showed that the SGRQ and the CRQ were normally distributed and that the BPQ was skewed toward low scores. Relationships between all dimensions of the three questionnaires were significant (correlation coefficients [Rs] = 0.74 to 0.86). The three questionnaires had significant but weak correlations (Rs = -0.24 to -0.36) with some physiologic variables (VC, FEV1, and DL(CO)/VA) and mild to moderate correlations with exercise capacity and assessment of dyspnea, anxiety, and depression. Stepwise multiple regression analyses revealed that the Baseline Dyspnea Index (BDI) score, anxiety by the Hospital Anxiety Depression Scale (HAD), and maximal oxygen uptake (VO2max) accounted for 61% of the variance in the SGRQ and that the BDI and anxiety of the HAD accounted for 53 and 49% of the variance in the BPQ and the CRQ, respectively. Dyspnea and psychologic status impacted the HRQL in patients with COPD. Although no substantial differences between the SGRQ, the BPQ, and the CRQ were evident in the correlations with physiologic parameters and the influential factors, the BPQ was found to be less discriminatory than the SGRQ and the CRQ in evaluating HRQL cross-sectionally.