Development of parathyroid glands
Development of parathyroid glands
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DOI：
10.1007/0-387-27530-4_1
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发表时间：
2005-01-01
期刊：
影响因子：
--
通讯作者：
Karsenty, G
中科院分区：
文献类型：
--
作者：
Günther, T;Karsenty, G
甲状旁腺（PG）是循环甲状旁腺激素（PTH）的主要来源，这种激素对钙和磷酸盐代谢的调节至关重要。PGs在胚胎发生期间由咽袋发育而来，并有内胚层细胞和神经嵴细胞的参与。一些基因被认为与PG的形成、迁移和分化有关。在大多数对转基因小鼠进行的研究中，可以证明Rae28， Hoxa3, Paxly， Pax9和Gcm2对于适当的PG形成是必不可少的。最近，与迪乔治综合症有关的候选基因也已被确定。
The parathyroid glands (PG) are the main source for circulating parathyroid hormone (PTH), a hormone that is essential for the regulation of calcium and phosphate metabolism. The PGs develop during embryogenesis from the pharyngeal pouches with contributions from endodermal and neural crest cells. A few genes have been attributed to the formation, migration and differentiation of the PG anlage. In studies mostly done in genetically manipulated mice it could be demonstrated that Rae28, Hoxa3, Paxly Pax9 and Gcm2 are essential for proper PG formation. Recently, candidate genes involved in the DiGeorge syndrome have been identified as well.