The ARF tumour suppressor
The ARF tumour suppressor
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DOI：
10.1016/j.biocel.2006.02.008
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发表时间：
2006-01-01
影响因子：
4
通讯作者：
Rizos, Helen
中科院分区：
文献类型：
--
作者：
Gallagher, Stuart J.;Kefford, Richard F.;Rizos, Helen
ARF肿瘤抑制因子是INK4alARF基因座的产物；一个在人类癌症中经常被改变的序列。ARF受致癌刺激上调，并通过与mdm2和ARF- bp1 /Mule泛素连接酶的相互作用成为p53稳定性的关键调节因子。细胞应激信号将ARF从核仁中释放出来，并与B23/核磷蛋白结合。ARF的核核位置可能作为快速诱导p53的储存库，但也可能对细胞周期、存活和生长起协调作用。ARF与其他结合伙伴相互作用的生物学功能尚不确定，但ARF介导的summoylation可能代表了一种统一的效应途径。(c) 2006 Elsevier Ltd.版权所有。
The ARF tumour suppressor is a product of the INK4alARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/nucleophosmin. This nucleolar location of ARF may serve as a reservoir for the rapid induction of p53, but may also serve to co-ordinate effects on cell cycle, survival and growth. The biological functions of ARF interactions with other binding partners remain uncertain, but ARF-mediated sumoylation may represent a unifying effector pathway. (c) 2006 Elsevier Ltd. All rights reserved.