Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type I highly exposed, persistently seronegative female sex workers in northern Thailand
Epidemiologic and biologic characterization of a cohort of human immunodeficiency virus type I highly exposed, persistently seronegative female sex workers in northern Thailand
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DOI：
10.1086/314556
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发表时间：
1999-01-01
影响因子：
6.4
通讯作者：
Natpratan, C
中科院分区：
文献类型：
--
作者：
Beyrer, C;Artenstein, AW;Natpratan, C
人高度暴露于人类免疫缺陷病毒（HIV）-1谁保持未感染的特征可能有助于定义保护性免疫17 HIV-1-血清阴性的泰国女性性工作者（CSW）暴露于HIV-1的流行病学证据进行了研究，体液免疫反应和HLA I类和CCR 5等位基因的表型和基因型分析。感染的CSW和低风险的HIV-1血清阴性的泰国妇女作为对照。高暴露、持续血清阴性（HEPS）的CSW与HIV感染的CSW在HIV风险、安全套使用或性传播疾病方面没有差异。在体液免疫反应中观察到显著差异：在13名HEPS CSW中的6名中的宫颈阴道灌洗液中检测到gp 160特异性伊加反应，但在21名血清阴性受试者中检测到0。所有妇女都有野生型CCR 5，HEPS CSW比匹配的对照组更有可能具有HLA-B18表型和基因型（校正P= 0.018），流行病学暴露于HIV-1而无明显感染，HLA I类等位基因的异常分布和HIV-1 gp 160特异性伊加应答表明这种现象的生物学基础。
Characterization of persons highly exposed to human immunodeficiency virus (HIV)-1 who remain uninfected may help define protective immunity Seventeen HIV-l-seronegative Thai female sex workers (CSWs) with epidemiologic evidence of exposure to HIV-1 were studied for humoral immune responses and phenotypic and genotypic analyses of HLA class I and CCR5 allelic profiles. Infected CSWs and low-risk HIV-l-seronegative Thai women were controls. Highly exposed, persistently seronegative (HEPS) CSWs did not differ from HIV-infected CSWs in HIV risks, condom use, or sexually transmitted diseases. Significant differences were seen in humoral immune responses: gp160-specific IgA responses were detected in cervicovaginal lavage fluids in 6 of 13 HEPS CSWs but 0 of 21 seronegative subjects. All women had wild-type CCR5, HEPS CSWs were more likely to have the HLA-B18 phenotype and genotype than were matched controls (corrected P=.018), Epidemiologic exposure to HIV-1 without apparent infection, an unusual distribution of HLA class I alleles, and HIV-1 gp160-specific IgA responses suggest a biologic basis for this phenomenon.