VITAMIN-D DEFICIENCY IN HOMEBOUND ELDERLY PERSONS
VITAMIN-D DEFICIENCY IN HOMEBOUND ELDERLY PERSONS
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DOI：
10.1001/jama.274.21.1683
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发表时间：
1995-12-06
影响因子：
120.7
通讯作者：
TOBIN, JD
中科院分区：
文献类型：
--
作者：
GLOTH, FM;GUNDBERG, CM;TOBIN, JD
客观。-为了评估维生素D的状态在居家，社区居住的老年人;缺乏阳光的老年疗养院居民;和健康，走动的老年人。一项队列分析研究。内裤。-在244名年龄至少为65岁的受试者中，116名受试者（85名女性和31名男性）已被限制在室内至少6个月，无论是在社区的私人住宅（霍普金斯老人院计划）还是在教学疗养院（约翰霍普金斯老年病中心）。128名对照受试者，一个健康的走动组，来自巴尔的摩老龄化纵向研究。所有受试者均无可能干扰其维生素D状态的疾病或药物。测定所有受试者的血清25-羟维生素D（25-OHD）和1，25-二羟维生素D（1，25-[OH]D-2）水平。在一个80名受试者的亚组中，评估了血清全段甲状旁腺激素（PTH）、离子钙和骨钙素水平以及维生素D摄入量（通过3天的食物记录）。一个随机选择的队列的阳光剥夺的受试者也有血清维生素D结合蛋白的测量水平。在阳光剥夺受试者中，平均25-OHD水平为30 nmol/L（12 ng/mL）（范围，
Objective.-To assess the vitamin D status in homebound, community-dwelling elderly persons; sunlight-deprived elderly nursing home residents; and healthy, ambulatory elderly persons.Design.-A cohort analytic study.Participants.-Of 244 subjects at least 65 years old, 116 subjects (85 women and 31 men) had been confined indoors for at least 6 months, either in private dwellings in the community (the Hopkins Elder Housecall Program) or in a teaching nursing home (The Johns Hopkins Geriatrics Center). The 128 control subjects, a healthy ambulatory group, came from the Baltimore Longitudinal Study on Aging. All subjects were free of diseases or medications that might interfere with their vitamin D status.Main Outcome measures.-Serum levels of 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-[OH]D-2) were measured in all subjects. In a subgroup of 80 subjects, serum levels of intact parathyroid hormone (PTH), ionized calcium, and osteocalcin and intake of vitamin D (through 3-day food records) were assessed. A randomly selected cohort of sunlight-deprived subjects also had serum levels of vitamin D binding protein measured.Results.-In sunlight-deprived subjects overall, the mean 25-OHD level was 30 nmol/L (12 ng/mL) (range,