Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling.
Dynamic magnetic resonance imaging of cerebral blood flow using arterial spin labeling.
复制标题
使用动脉自旋标记对脑血流进行动态磁共振成像。
DOI：
10.1007/978-1-59745-543-5_13
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Paiva,FernandoF
中科院分区：
文献类型：
--
作者：
Silva,AfonsoC;Paiva,FernandoF
现代功能神经成像技术，包括正电子发射断层扫描、内在信号的光学成像和磁共振成像(MRI)，依赖于神经活动和脑血流量(CBF)之间的紧密耦合，以CBF作为替代标记物来可视化脑活动。由于神经成像方式的空间和时间分辨率最终由基础血流动力学信号的空间和时间特异性决定，因此表征对局灶性脑刺激的血流动力学响应的空间和时间分布对于正确解释和量化功能数据至关重要。用MRI正确测量和量化脑血流量的能力是我们对大脑功能理解取得进展的主要决定因素。我们回顾了动态动脉自旋标记(DASL)方法测量脑血流和高时间分辨率的脑血流功能反应。
Modern functional neuroimaging techniques, including positron emission tomography, optical imaging of intrinsic signals, and magnetic resonance imaging (MRI) rely on a tight coupling between neural activity and cerebral blood flow (CBF) to visualize brain activity using CBF as a surrogate marker. Because the spatial and temporal resolution of neuroimaging modalities is ultimately determined by the spatial and temporal specificity of the underlying hemodynamic signals, characterization of the spatial and temporal profiles of the hemodynamic response to focal brain stimulation is of paramount importance for the correct interpretation and quantification of functional data. The ability to properly measure and quantify CBF with MRI is a major determinant of progress in our understanding of brain function. We review the dynamic arterial spin labeling (DASL) method to measure CBF and the CBF functional response with high temporal resolution.