Disseminins and Spiciferone Analogues: Polyketide-Derived Metabolites from a Fungicolous Isolate of Pestalotiopsis disseminata.
Disseminins and Spiciferone Analogues: Polyketide-Derived Metabolites from a Fungicolous Isolate of Pestalotiopsis disseminata.
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DOI：
10.1021/acs.jnatprod.5b00907
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发表时间：
2016-03
影响因子：
5.1
通讯作者：
In Hyun Hwang;D. Swenson;J. Gloer;D. Wicklow
中科院分区：
文献类型：
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作者：
In Hyun Hwang;D. Swenson;J. Gloer;D. Wicklow
从传播拟盘拟盘菌 (NRRL 62562) 真菌分离株的培养物中获得了 7 种新的聚酮化合物代谢物（传播素 A-E、1-5，以及 spiciferones D 和 E、7 和 8），以及以前仅作为半合成产品已知的相关化合物 (6)。结构主要通过HRMS和NMR数据分析来确定。生物遗传学相关的化合物1和2分别具有不常见的双四氢呋喃和二氧杂双环[3.2.1]辛烷环系统。 1 的对溴苯甲酸酯衍生物的 X 射线晶体学分析证实了其结构并确定了其绝对构型。
Seven new polyketide metabolites (disseminins A-E, 1-5, and spiciferones D and E, 7 and 8) were obtained from cultures of a fungicolous isolate of Pestalotiopsis disseminata (NRRL 62562), together with a related compound (6) previously known only as a semisynthetic product. Structures were determined mainly by analysis of HRMS and NMR data. Biogenetically related compounds 1 and 2 possess uncommon bis-tetrahydrofuran and dioxabicyclo[3.2.1]octane ring systems, respectively. X-ray crystallographic analysis of the p-bromobenzoate derivative of 1 confirmed the structure and enabled assignment of its absolute configuration.