Vestibular signals in macaque extrastriate visual cortex are functionally appropriate for heading perception.
Vestibular signals in macaque extrastriate visual cortex are functionally appropriate for heading perception.
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DOI：
10.1523/jneurosci.1607-09.2009
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发表时间：
2009-07-15
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影响因子：
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通讯作者：
Angelaki DE
中科院分区：
文献类型：
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作者：
Liu S;Angelaki DE
视觉和前庭信号汇聚到猕猴纹外视皮层的背侧内侧上颞区(MSTd)，该区域被认为参与了空间导航的多感官航向知觉。然而，周围耳石信息是模棱两可的，不能区分在自我运动过程中经历的线性加速度和由于空间方向相对于重力的变化而产生的线性加速度。在这里，我们表明，不同于外周前庭感受器，但类似于小脑蚯蚓(小脑小结和悬垂)的第9和10小叶，MSTd神经元对标题有选择性地反应，而不是对相对于重力方向的变化做出反应。在航向知觉中，MSTd前庭反应也受类似速度的时间动力学支配，这可能会优化感觉与视觉运动信息的整合。然而，与小脑蚯蚓不同的是，MSTd神经元还携带来自半规管的空间方向独立的旋转信号，这可能有助于补偿头部旋转对光流处理的影响。这些发现表明，MSTd中的前庭信号得到了适当的处理，以支持多感觉航向知觉的功能作用。
Visual and vestibular signals converge onto the dorsal medial superior temporal area (MSTd) of the macaque extrastriate visual cortex, which is thought to be involved in multisensory heading perception for spatial navigation. Peripheral otolith information, however, is ambiguous and cannot distinguish linear accelerations experienced during self-motion from those due to changes in spatial orientation relative to gravity. Here we show that, unlike peripheral vestibular sensors but similar to lobules 9 and 10 of the cerebellar vermis (nodulus and uvula), MSTd neurons respond selectively to heading and not to changes in orientation relative to gravity. In support of a role in heading perception, MSTd vestibular responses are also dominated by velocity-like temporal dynamics, which might optimize sensory integration with visual motion information. Unlike the cerebellar vermis, however, MSTd neurons also carry a spatial orientation-independent rotation signal from the semicircular canals, which could be useful in compensating for the effects of head rotation on the processing of optic flow. These findings show that vestibular signals in MSTd are appropriately processed to support a functional role in multisensory heading perception.