Recent insights into the biological activities and drug delivery systems of tanshinones.
Recent insights into the biological activities and drug delivery systems of tanshinones.
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对丹参酮生物活性和药物输送系统的最新见解
DOI：
10.2147/ijn.s84035
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发表时间：
2016
影响因子：
8
通讯作者：
Chen M
中科院分区：
文献类型：
--
作者：
Cai Y;Zhang W;Chen Z;Shi Z;He C;Chen M
丹参酮是中药丹参（丹参）的主要脂溶性药理成分，因其在生物医学上的应用前景而受到越来越多的科学关注。丹参酮中的三种主要生物活性成分，即丹参酮I （TNI）、丹参酮IIA （TNIIA）和隐丹参酮（CPT），具有多种药理活性，包括抗炎、抗癌和心脑血管保护活性。然而，由于TNI、TNIIA和CPT的溶解度差、溶出率低，限制了它们的临床应用。为了解决这些问题，许多研究集中在将丹参酮装入脂质体、纳米颗粒、微乳液、环糊精包裹体、固体分散体等中。本文就丹参酮的生物活性和给药系统进行综述，为其临床应用提供参考。
Tanshinones, the major lipid-soluble pharmacological constituents of the Chinese medicinal herb Tanshen (Salvia miltiorrhiza), have attracted growing scientific attention because of the prospective biomedical applications of these compounds. Numerous pharmacological activities, including anti-inflammatory, anticancer, and cardio-cerebrovascular protection activities, are exhibited by the three primary bioactive constituents among the tanshinones, ie, tanshinone I (TNI), tanshinone IIA (TNIIA), and cryptotanshinone (CPT). However, due to their poor solubility and low dissolution rate, the clinical applications of TNI, TNIIA, and CPT are limited. To solve these problems, many studies have focused on loading tanshinones into liposomes, nanoparticles, microemulsions, cyclodextrin inclusions, solid dispersions, and so on. In this review, we aim to offer an updated summary of the biological activities and drug delivery systems of tanshinones to provide a reference for these constituents in clinical applications.