High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia
High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia
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DOI：
10.1038/jcbfm.2009.202
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发表时间：
2010-02
影响因子：
6.3
通讯作者：
Qing-Wu Yang;Jing-zhou Wang;Jing-cheng Li;Yu Zhou;Qi Zhong;F. Lu;Jing Xiang
中科院分区：
文献类型：
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作者：
Qing-Wu Yang;Jing-zhou Wang;Jing-cheng Li;Yu Zhou;Qi Zhong;F. Lu;Jing Xiang
高迁移率族蛋白1（HMGB1）最初被鉴定为广泛表达的、丰富的、非组蛋白DNA结合蛋白。它在维持核内稳态方面具有公认的功能。HMGB1可以响应于坏死信号被动释放到细胞外环境中，也可以响应于炎症信号主动分泌。细胞外HMGB1与受体相互作用，包括晚期糖基化终产物（RAGE）以及Toll样受体2（TLR2）和TLR4。HMGB1与其他促炎介质以协同方式发挥作用，并作为一种有效的促炎性丝氨酸样因子，有助于多种炎症和感染性疾病的发病机制。许多报告指出HMGB1是缺血性脑中的一个新角色。本文综述了HMGB1在脑缺血损伤中的新作用，强调了HMGB1阻断剂作为神经保护的有效治疗工具的相关性。
High-mobility group box-1 (HMGB1) was originally identified as a ubiquitously expressed, abundant, nonhistone DNA-binding protein. It has well-established functions in the maintenance of nuclear homeostasis. The HMGB1 can either be passively released into the extracellular milieu in response to necrotic signals or actively secreted in response to inflammatory signals. Extracellular HMGB1 interacts with receptors, including those for advanced glycation endproducts (RAGEs) as well as Toll-like receptor 2 (TLR2) and TLR4. The HMGB1 functions in a synergistic manner with other proinflammatory mediators and acts as a potent proinflammatory cytokine-like factor that contributes to the pathogenesis of diverse inflammatory and infectious disorders. Numerous reports point to HMGB1 as a novel player in the ischemic brain. This review provides an appraisal of the emerging roles of HMGB1 in cerebral ischemia injury, highlighting the relevance of HMGB1-blocking agents as potent therapeutic tools for neuroprotection.