MicroRNAs in normal and malignant hematopoiesis
MicroRNAs in normal and malignant hematopoiesis
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DOI：
10.1097/moh.0b013e328303e15d
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发表时间：
2008-07-01
影响因子：
3.2
通讯作者：
Croce, Carlo M.
中科院分区：
文献类型：
--
作者：
Garzon, Ramiro;Croce, Carlo M.
综述的目的一类新的基因调控因子的发现，命名为microRNA，改变了人类遗传学的景观。在造血方面，最近的工作提高了我们对microRNA在造血分化和白血病发生中的作用的理解。最近的发现使用经工程改造以过表达miR-150、miR-17（类似于92）和miR-155或缺乏miR-223、miR-155和miR-17（类似于92）表达的动物模型，几个研究小组现在已经表明，miRNA对B淋巴细胞发育至关重要（miR-150和miR-17类似于92）、粒细胞生成（miR-223）、免疫功能（miR-155）和B淋巴细胞增生性疾病（miR-155和miR-17类似于92）。独特的miRNA特征已被描述与细胞遗传学和急性髓细胞白血病的结果。SummaryThere现在有强有力的证据表明，miRNA不仅调节造血分化和增殖，而且还调节造血细胞的活性，特别是那些与免疫功能相关的细胞。在白血病和淋巴瘤中已经观察到广泛的miRNA失调，并且机制研究支持miRNA在这些疾病的发病机制中的作用。
Purpose of reviewThe discovery of a novel class of gene regulators, named microRNAs, has changed the landscape of human genetics. In hematopoiesis, recent work has improved our understanding of the role of microRNAs in hematopoietic differentiation and leukemogenesis.Recent findingsUsing animal models engineered to overexpress miR-150, miR-17 similar to 92 and miR-155 or to be deficient for miR-223, miR-155 and miR-17 similar to 92 expression, several groups have now shown that miRNAs are critical for B-lymphocyte development (miR-150 and miR-17 similar to 92), granulopoiesis (miR-223), immune function (miR-155) and B-lymphoproliferative disorders (miR-155 and miR-17 similar to 92). Distinctive miRNA signatures have been described in association with cytogenetics and outcome in acute myeloid leukemia.SummaryThere is now strong evidence that miRNAs modulate not only hematopoietic differentiation and proliferation but also activity of hematopoietic cells, in particular those related to immune function. Extensive miRNA deregulation has been observed in leukemias and lymphomas and mechanistic studies support a role for miRNAs in the pathogenesis of these disorders.