Unique Blood Pressure Characteristics in Mother and Offspring After Early Onset Preeclampsia
Unique Blood Pressure Characteristics in Mother and Offspring After Early Onset Preeclampsia
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DOI：
10.1161/hypertensionaha.112.198366
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发表时间：
2012-11-01
期刊：
影响因子：
8.3
通讯作者：
Leeson, Paul
中科院分区：
文献类型：
--
作者：
Lazdam, Merzaka;de la Horra, Arancha;Leeson, Paul
如果先兆子痫在怀孕早期发展，母亲和子代患高血压的风险更大。我们调查了那些早期发病的人是否有独特的不良血压特征。140名妇女在妊娠合并先兆子痫6至13年后(妊娠34周前45名早发型子痫前期妇女和45名晚发性先兆子痫妇女)或正常血压妊娠后(50名妇女)进行了研究。这些怀孕的47个后代也参加了实验。母亲产前和产后血压的数据从产后记录中提取，并与以后生活中的外周、中枢和动态血压测量有关。与晚发性子痫前期相比，早发性子痫前期患者出生后6周舒张压升高(86.25+/-13.46对75.00+/-5.00 mm Hg，P
Risk of hypertension in mother and offspring after preeclampsia is greater if preeclampsia develops early in pregnancy. We investigated whether those who develop early onset disease have unique adverse blood pressure characteristics. One hundred forty women were studied 6 to 13 years either after a pregnancy complicated by preeclampsia (45 women with early onset preeclampsia before 34 weeks gestation and 45 women with late-onset preeclampsia) or after a normotensive pregnancy (50 women). Forty-seven offspring from these pregnancies also participated. Data on maternal antenatal and postnatal blood pressures were extracted from maternity records and related to peripheral, central, and ambulatory blood pressure measurements in later life. Compared with late-onset preeclampsia, early onset preeclampsia was associated with higher diastolic blood pressure 6 weeks postnatally (86.25 +/- 13.46 versus 75.00 +/- 5.00 mm Hg, P