Cathepsins in digestive cancers.
Cathepsins in digestive cancers.
复制标题
消化道癌症中的组织蛋白酶
DOI：
10.18632/oncotarget.16677
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发表时间：
2017-06-20
期刊：
影响因子：
--
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Chen S;Dong H;Yang S;Guo H
组织蛋白酶是属于木瓜蛋白酶家族的溶酶体肽酶，并且基于它们的催化位点，这些酶可以被分为丝氨酸、半胱氨酸和天冬氨酸蛋白酶。迄今为止进行的研究已经确定了15种广泛分布于细胞内和细胞外空间的组织蛋白酶。这些蛋白酶参与各种病理活动，包括人类癌症的发生和发展。最近的一些研究表明，组织蛋白酶，特别是组织蛋白酶B，D，E和L，有助于消化道肿瘤的发生。组织蛋白酶被发现促进大多数消化道癌症的发展，除了肝癌，在肝癌中它们可能具有相反的作用。由于组织蛋白酶在消化道肿瘤中的重要作用，其可能成为消化道肿瘤治疗的靶点。
Cathepsins are lysosomal peptidases belonging to the papain family, and based on their catalytic sites, these enzymes can be divided into serine, cysteine and aspartic proteases. The studies conducted to date have identified, 15 types of cathepsins that are widely distributed in intracellular and extracellular spaces. These proteases participate in various pathological activities, including the occurrence and development of human cancers. Several recent studies suggest that cathepsins, particularly cathepsins B, D, E and L, contribute to digestive tumorigenesis. Cathepsins were found to promote the development of most digestive cancers except liver cancer, in which they might have the opposite effects. Due to their important roles in digestive tumors, cathepsins might be therapeutic targets for the treatment of digestive cancers.