Multiclass method for fast determination of veterinary drug residues in baby food by ultra-high-performance liquid chromatography-tandem mass spectrometry
Multiclass method for fast determination of veterinary drug residues in baby food by ultra-high-performance liquid chromatography-tandem mass spectrometry
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DOI：
10.1016/j.foodchem.2011.12.042
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发表时间：
2012-06-15
期刊：
影响因子：
8.8
通讯作者：
Garrido Frenich, A.
中科院分区：
文献类型：
--
作者：
Aguilera-Luiz, M. M.;Martinez Vidal, J. L.;Garrido Frenich, A.
建立了一种快速测定肉基婴儿食品（MBF）和奶粉基婴儿配方奶粉（PMIF）中不同兽药残留的方法。该方法采用缓冲QuEChERS（快速、简便、廉价、有效、坚固、安全）萃取方法，无需进一步的清理步骤，然后采用超高效液相色谱-串联质谱（UHPLC-MS/MS）进行萃取。该方法在三种不同浓度水平的两种婴儿食品基质（MBF和PMIF）中进行了验证，获得了合适的回收率和精密度（日内精密度）值。采用矩阵匹配标准校准进行定量。决策极限（CC alpha）和决策能力（CC beta）分别为0.5 ~ 16.2 μ g/kg和1.2 ~ 22.4 μ g/kg。最后，将该方法应用于几种婴儿食品样品的分析，检测出部分兽药的痕量。(C) 2011 Elsevier Ltd.版权所有。
A simple and rapid multiresidue method for the determination of different veterinary drug residues in meat-based baby food (MBF) and powdered milk-based infant formulae (PMIF) has been developed. The method involves an extraction procedure based on buffered QuEChERS (quick, easy, cheap, effective, rugged and safe) methodology, without any further clean-up step, followed by ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS). The method has been validated in two baby food matrices (MBF and PMIF) at three different concentration levels, obtaining suitable recoveries and precision (inter and intra-day precision) values. Quantification was carried out using matrix-matched standard calibration. Furthermore, the decision limit (CC alpha) and the decision capability (CC beta) were evaluated, ranging from 0.5 to 16.2 mu g/kg and from 1.2 to 22.4 mu g/kg, respectively. Finally, the method was applied to the analysis of several kinds of baby food samples and traces of some veterinary drugs were detected. (C) 2011 Elsevier Ltd. All rights reserved.