INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS
INVITRO SELECTION OF RNA MOLECULES THAT BIND SPECIFIC LIGANDS
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DOI：
10.1038/346818a0
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发表时间：
1990-08-30
期刊：
影响因子：
64.8
通讯作者：
SZOSTAK, JW
中科院分区：
文献类型：
--
作者：
ELLINGTON, AD;SZOSTAK, JW
已经从随机序列RNA分子的群体中分离出特异性结合多种有机染料的RNA分子亚群。大约每1010个随机序列RNA分子中就有一个以这样的方式折叠，从而为小配体创造一个特异性结合位点。
Subpopulations of RNA molecules that bind specifically to a variety of organic dyes have been isolated from a population of random sequence RNA molecules. Roughly one in 1010random sequence RNA molecules folds in such a way as to create a specific binding site for small ligands.