The utilization of copper flow reactors in organic synthesis
The utilization of copper flow reactors in organic synthesis
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DOI：
10.1039/c4cc09221j
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Tranmer, Geoffrey K.
中科院分区：
文献类型：
--
作者：
Bao, Jennifer;Tranmer, Geoffrey K.
流动化学技术的使用在过去十年中蓬勃发展，近年来该领域不断扩大，包括在台式有机合成中使用铜流动反应器。这些反应器有多种形式，并且在安全性和产率方面比间歇式反应同类产品具有许多优势。本综述将重点介绍当前使用铜流反应器的研究，例如 1,3-偶极环加成（“点击”化学）、大环化（通过“点击”化学）、Sonogashira C-C 偶联、乌尔曼偶联、脱羧和其他报道的发现。
The use of flow chemistry techniques has flourished over the past decade, with the field expanding to include the use of copper flow reactors in bench-top organic synthesis in recent years. These reactors are available in a variety of forms and possess a number of advantages over their batch reaction counterparts, in terms of both safety and yield. This review will highlight the current research employing copper flow reactors, such as 1,3-dipolar cycloadditions ('click' chemistry), macrocyclizations (via 'click' chemistry), Sonogashira C-C couplings, Ullmann couplings, decarboxylations, and other reported findings.