Anaemia in systemic lupus erythematosus: aetiological profile and the role of erythropoietin
Anaemia in systemic lupus erythematosus: aetiological profile and the role of erythropoietin
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DOI：
10.1136/ard.59.3.217
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发表时间：
2000-03-01
影响因子：
27.4
通讯作者：
Moutsopoulos, HM
中科院分区：
文献类型：
--
作者：
Voulgarelis, M;Kokori, SIG;Moutsopoulos, HM
目的：研究系统性红斑狼疮（SLE）患者不同病因贫血的发生率及其与免疫学和临床指标的关系，并评价促红细胞生成素（Epo）和抗促红细胞生成素（抗Epo）在SLE贫血中的作用。方法：132例SLE贫血患者，在本研究中，前瞻性地招募了来自总共345名连续SLE患者中的10名患者（定义为女性血红蛋白为12 g/dl或更低，男性血红蛋白为13.5 g/dl或更低）。结果确定的原因是慢性病贫血（ACD）n=49（37.1%），缺铁性贫血（IDA）n = 47（35.6%），自身免疫性溶血性贫血（AHA）n=19（14.4%）和其他原因n=17（12.9%）。四组间贫血严重程度存在显著异质性（p
Objective-To study the prevalence of different causes of anaemia in patients with systemic lupus erythematosus (SLE) and their associations with immunological and clinical parameters and to evaluate the contribution of erythropoietin (Epo) and anti-erythropoietin (anti-Epo) autoantibodies to the development of SLE anaemia.Methods-132 SLE patients with anaemia (defined as haemoglobin of 12 g/dl or less for women and 13.5 g/dl or less for men) from among a total of 345 consecutive SLE patients were prospectively enrolled into the study. Standard haematological and immunological tests were performed and serum Epo and anti-Epo antibodies were assayed.Results-The identified causes were anaemia of chronic disease (ACD) n=49 (37.1%), iron deficiency anaemia (IDA) n=47 (35.6%), autoimmune haemolytic anaemia (AHA) n=19 (14.4%) and other causes n=17 (12.9%). There was significant heterogeneity in the severity of anaemia between the four groups (p