SIBLING CORRELATIONS AND SEGREGATION ANALYSIS OF AGE-RELATED MACULOPATHY - THE BEAVER DAM EYE STUDY
SIBLING CORRELATIONS AND SEGREGATION ANALYSIS OF AGE-RELATED MACULOPATHY - THE BEAVER DAM EYE STUDY
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DOI：
10.1002/gepi.1370110106
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发表时间：
1994-01-01
影响因子：
2.1
通讯作者：
KLEIN, R
中科院分区：
文献类型：
--
作者：
HEIBA, IM;ELSTON, RC;KLEIN, R
在海狸水坝眼科研究中，对来自564个家庭的个体的右眼和左眼的年龄相关性黄斑病变评分进行了兄弟姐妹相关性评估和分离分析。有证据表明，兄弟姐妹之间存在显著的相关性。这些数据符合两种正态分布的混合，特别是在经历Box和Cox幂变换之后。在每只眼睛中，孟德尔传递的主要效应的假设在tau(AB)自由模型下不能被拒绝，但在tau的自由模型下被拒绝。随机环境主要效应的假设被拒绝了。两只眼睛的主基因参数估计值相似。结果与决定年龄相关性黄斑病变评分的主要效应相一致，分别为右眼和左眼的62%和59%。在右眼和左眼中，由于主要效应，单个主基因可分别解释约89%和97%的这种变异，或分别约占总变异的55%和57%。(C)1994年Wiley-Liss，Inc.
Sibling correlations were evaluated and segregation analysis was performed on age-dependent maculopathy scores of the right and left eyes of individuals from 564 families in the Beaver Dam Eye study. There is evidence of significant sibling correlations. The data fit a mixture of two normal distributions, especially after undergoing the Box and Cox power transformation. In each eye, the hypothesis of mendelian transmission of a major effect cannot be rejected under the tau(AB) free model, but is rejected under the tau's free model. The hypothesis of a random environmental major effect is rejected. Similar major gene parameter estimates are found for both eyes. The results are consistent with a major effect accounting for 62% and 59%, in the right and left eyes, respectively, of the determination of age-related maculepathy scores. A single major gene can account for about 89% and 97% of this variability due to a major effect, or for about 55% and 57% of the total variability, in the right and left eyes, respectively. (C) 1994 Wiley-Liss, Inc.