Ebselen prevents noise-induced excitotoxicity and temporary threshold shift
Ebselen prevents noise-induced excitotoxicity and temporary threshold shift
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DOI：
10.1016/j.neulet.2005.01.047
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发表时间：
2005-06
影响因子：
2.5
通讯作者：
T. Yamasoba;A. Pourbakht;Takashi Sakamoto;Mitsuya Suzuki
中科院分区：
文献类型：
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作者：
T. Yamasoba;A. Pourbakht;Takashi Sakamoto;Mitsuya Suzuki
本研究验证了噪声诱导的暂时性阈移（TTS）可以被过氧亚硝酸根清除剂ebselen（2-苯基-1，2-苯并异硒唑-3（2 H）-酮）衰减的假设。豚鼠在暴露于115 dBSPL 4-kHz倍频程噪声3 h前1h口服溶剂或10 mg/kg依布硒啉。对照组听性脑干反应（ABR）阈值在噪声暴露后即刻升高25- 45 dB，7天后恢复到暴露前的基线阈值。Ebselen消除了噪声暴露后的ABR阈值偏移。在对照组中，肿胀的传入树突下的内毛细胞是明显的噪音后立即，而依布硒啉显着减少这种病理。这些研究结果表明，清除过氧亚硝酸盐可以减弱噪声引起的兴奋性毒性，从而，TTS。
This investigation tested the hypothesis that a noise-induced temporary threshold shift (TTS) can be attenuated by a peroxynitrite scavenger, ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one). Guinea pigs received an oral dose of the vehicle or 10mg/kg ebselen 1h before exposure to 115dB SPL 4-kHz octave band noise for 3h. In controls, auditory brainstem response (ABR) thresholds increased by 25–45dB immediately after noise and returned to pre-exposure baseline thresholds 7 days later. Ebselen eliminated this ABR threshold shift following noise exposure. In controls, swelling of the afferent dendrites beneath the inner hair cells was evident immediately after noise, whereas ebselen significantly reduced this pathology. These findings suggest that scavenging peroxynitrite can attenuate noise-induced excitotoxicity and, thereby, TTS.