Pulmonary Embolism and Gas Exchange
Pulmonary Embolism and Gas Exchange
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DOI：
10.1159/000501342
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发表时间：
2019-09-01
期刊：
影响因子：
3.7
通讯作者：
de Souza, Rogerio
中科院分区：
文献类型：
--
作者：
Fernandes, Caio J.;Luppino Assad, Ana Paula;de Souza, Rogerio
急性肺栓塞（PE）损害血流动力学、气体交换和肺机械能力。考虑到PE的病理生理学，最关注的是血流动力学损害。然而，PE患者最常见的症状来自气体交换改变，多年来一直没有受到关注。肺生理学和随之而来的气体交换障碍在PE死亡的高风险中起着关键作用。在这篇综述中，我们将着眼于PE的病理生理学，从血管闭塞到由此产生的肺灌注和气体交换障碍的异质性，详细讨论其原因和后果。
Acute pulmonary embolism (PE) impairs hemodynamics, gas exchange, and lung mechanical capacity. Considering PE pathophysiology, most attention has been paid to hemodynamic impairment. However, the most prevalent symptoms in PE patients come from gas exchange alterations, which have not been in the spotlight for many years. Pulmonary physiology and consequent gas exchange impairment play a pivotal role in the high risk of death from PE. In this review, we will look at the pathophysiology of PE, from the vascular occlusion to the resultant heterogeneity in pulmonary perfusion and gas exchange impairment, discussing in detail its causes and consequences.