Detection of neural activity using phase-sensitive optical low-coherence reflectometry
Detection of neural activity using phase-sensitive optical low-coherence reflectometry
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DOI：
10.1364/opex.12.002377
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发表时间：
2004-05-31
期刊：
影响因子：
3.8
通讯作者：
Rylander, HG
中科院分区：
文献类型：
--
作者：
Akkin, T;Davé, DP;Rylander, HG
我们演示了与动作电位传播相关的神经表面位移的非接触式亚纳米光学测量。使用相敏光学低相干反射计记录从小龙虾行走腿解剖的神经束的实验结果。不使用外源化学品或反射涂层。瞬时神经表面位移的幅度小于 1 nm，持续时间为 1 ms，并且与到达光学测量部位的动作电位一致。由于该技术使用背反射光，因此可以对各种神经病变进行无创检测。 (C) 2004 年美国光学学会。
We demonstrate non-contact sub-nanometer optical measurement of neural surface displacement associated with action potential propagation. Experimental results are recorded from nerve bundles dissected from crayfish walking leg using a phase-sensitive optical low coherence reflectometer. No exogenous chemicals or reflection coatings are applied. Transient neural surface displacement is less than 1 nm in amplitude, 1 ms in duration and is coincident with action potential arrival to the optical measurement site. Because the technique uses back-reflected light, noninvasive detection of various neuropathies may be possible. (C) 2004 Optical Society of America.