Nitrite catalyzes reductive nitrosylation of the water-soluble ferri-heme model FeIII(TPPS) to FeII(TPPS)(NO)
Nitrite catalyzes reductive nitrosylation of the water-soluble ferri-heme model FeIII(TPPS) to FeII(TPPS)(NO)
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DOI：
10.1021/ic020519r
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发表时间：
2003-01-13
影响因子：
4.6
通讯作者：
Ford, PC
中科院分区：
文献类型：
--
作者：
Fernandez, BO;Lorkovic, IM;Ford, PC
铁-血红素模型化合物Fe-Ⅲ(TPPS)(H2O)(2)(1)在缓冲水溶液中生成Fe-II(TPPS)(NO)(2)(TPPS=四(4-磺酸苯基)卟啉)的定量研究表明，在pH为4-6的范围内，还原亚硝化反应是缓慢的，不依赖于pH。这个反应的速度受适度的一般碱催化作用的影响。在本研究过程中，发现了一种令人惊讶的催化途径，即亚硝酸根离子(NO2-)在还原亚硝化条件下强烈催化1到2的还原。
Quantitative investigation of the reaction of the ferri-heme model compound Fe-III(TPPS)(H2O)(2) (1) to give Fe-II(TPPS)(NO) (2) (TPPS = tetra(4-sulfonato-phenyl)porphinato) in buffered aqueous solution demonstrates a slow pH-independent reductive nitrosylation pathway in the pH range 4-6. The rate of this reaction is subject to modest general base catalysis. In the course of this study, a surprising catalytic pathway whereby nitrite ion (NO2-) strongly catalyzes the reduction of 1 to 2 under reductive nitrosylation conditions was demonstrated.