Smoking and Helicobacter pylori infection in a sample of US adults
Smoking and Helicobacter pylori infection in a sample of US adults
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DOI：
10.1097/01.ede.0000165365.52904.4a
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发表时间：
2005-07-01
期刊：
影响因子：
5.4
通讯作者：
Graham, DY
中科院分区：
文献类型：
--
作者：
Cardenas, VM;Graham, DY
背景：虽然国家健康和营养检查调查（NHANES）已经评估了幽门螺杆菌感染的患病率，但其与吸烟的可能关系尚未得到充分探讨。 方法：我们使用 1999-2000 年 NHANES 数据来检验吸烟是否影响成人幽门螺杆菌感染的患病率（n = 3689）。通过抗幽门螺杆菌评估，幽门螺杆菌感染的患病率。根据吸烟史和血清可替宁水平计算幽门螺杆菌 IgG 酶联免疫测定结果。结果：在控制可能的混杂因素后，当前吸烟与幽门螺杆菌感染患病率增加相关（患病率比值比 = 1.9；95% 置信区间 = 1.4-2.5）。通过血清可替宁增加来衡量，当前吸烟也与幽门螺杆菌感染患病率增加有关（1.6；1.3-2.0）。没有证据表明剂量反应关系。结论：吸烟可能导致幽门螺杆菌感染的持续存在。
Background: Although the prevalence of Helicobacter pylori infection has been assessed in the National Health and Nutritional Examination Survey (NHANES), its possible relation with smoking has not been fully explored.Methods: We used the 1999-2000 NHANES data to examine whether smoking affects the prevalence of H. pylori infection in adults (n = 3689). The prevalence of H. pylori infection, as assessed by anti-H. pylori IgG enzyme-linked immunoassay, was computed according to smoking history and levels of serum cotinine.Results: Current smoking was associated with an increased prevalence of H. pylori infection (prevalence odds ratio =1.9; 95% confidence interval = 1.4-2.5) after controlling for possible confounders. Current smoking, as measured by increased serum cotinine, was also associated with an increased prevalence of H. pylori infection (1.6; 1.3-2.0). There was no evidence of a dose-response relation.Conclusions: Smoking may contribute to the persistence of H. pylori infection.