Electrical stimulation of the paraventricular nucleus attenuates pyrogen fever in the rabbit.
Electrical stimulation of the paraventricular nucleus attenuates pyrogen fever in the rabbit.
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电刺激室旁核可减轻兔子的热原热。
DOI：
10.1016/0006-8993(92)91574-x
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Ruwe,WD
中科院分区：
文献类型：
--
作者：
Ruwe,WD
精氨酸加压素(AVP)在腹中隔区(VSA)内灌流，可抑制通常由热原物质引起的发热，包括马流产沙门氏菌(SAE)。位于室旁核(PVN)或邻近终纹床核(BNST)的含AVP的神经元被认为有向该隔区的投射。进行了一系列实验，以确定电刺激这些区域是否会同样影响发热的发病机制，这可能会导致VSA内AVP的释放。在22只雄性新西兰大白兔身上植入一个不锈钢导管，并通过该导管将单极电极降至PVN或BNST区。电刺激(20赫兹，10 S开，10 S关，2.6~3.2V)在静脉注射前30min开始，持续至90min。给予0.1mlSAE0.1-1.0mlSAEg(1.0ml载运载体)。μg。在不发热的体温不变的情况下，电刺激位于PVN吻部延伸部的部位有效地减轻了热原引起的发热。刺激这些区域以外的部位既不影响发烧的绝对程度，也不影响发烧的持续时间。虽然退烧在电刺激期间最为明显，但在某些情况下，即使在施加电流后，发烧仍被抑制。这些实验提供了第一个证据，证明电刺激含有AVP的细胞体的室旁区域在抑制全身注射热原引起的发热方面有效。尽管未经测试，但VSA内刺激诱导的AVP释放可能是退烧的原因。
Arginine vasopressin (AVP) perfused within the ventral septal area (VSA) suppresses fever normally evoked by pyrogenic substances, includingSalmonella abortus equi(SAE). Neurons containing AVP and located within the paraventricular nucleus (PVN) or the nearby bed nucleus of the stria terminalis (BnST) are believed to have projections to this septal region. A series of experiments was undertaken to determine whether electrical stimulation of these areas, which might be expected to cause the release of AVP within the VSA, would affect similarly the pathogenesis of fever. A stainless steel cannula was implanted surgically in each of 22 male New Zealand White rabbits and a monopolar electrode was lowered through this guide cannula to the PVN or BnST areas. Electrical stimulation (20 Hz, 10 s on, 10 s off, 2.6–3.2 V) was initiated 30 min prior to and was continued until 90 min after the intravenous (i.v.) adminisstration of 0.1–1.0 μg of SAE (1.0 ml carrier vehicle ). While afebrile body temperature remained unchanged, electrical stimulation of sites located in the rostral extension of the PVN effectively attenuated the pyrogen-induced fever. Stimulation of sites outside these areas did not affect either the absolute magnitude or the duration of the fever. Although the reduction in fever was most pronounced during the period of electrical stimulation, in some cases the fever remained suppressed beyond the application of the current. These experiments provide the first evidence that electrical stimulation of paraventricular areas with AVP-containing cell bodies is effective in suppressing a fever evoked by systemic administration of a pyrogen. Although untested, it is possible that a stimulus-induced release of AVP within the VSA is responsible for the attenuation of the fever.