RETICULAR PSEUDODRUSEN ON INFRARED IMAGING ARE TOPOGRAPHICALLY DISTINCT FROM SUBRETINAL DRUSENOID DEPOSITS ON EN FACE OPTICAL COHERENCE TOMOGRAPHY.
RETICULAR PSEUDODRUSEN ON INFRARED IMAGING ARE TOPOGRAPHICALLY DISTINCT FROM SUBRETINAL DRUSENOID DEPOSITS ON EN FACE OPTICAL COHERENCE TOMOGRAPHY.
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DOI：
10.1097/iae.0000000000000666
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Fawzi AA
中科院分区：
文献类型：
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作者：
Heiferman MJ;Fernandes JK;Munk M;Mirza RG;Jampol LM;Fawzi AA
目的探讨网状假性玻璃疣（RPD）的红外反射率（IR）和视网膜下玻璃疣样沉积物（SDD）在全脸体积光谱域光学相干断层扫描（SD-OCT）中的定量和局部关系。RPD由戴面罩的观察者标记在IR图像上。SDD在SD-OCT的外界膜下方的正面切片上可视化，并通过半自动技术识别。对照RPD病变在每个IR图像的随机分布中生成。对照和实验RPD和SDD的二进制地图合并，并在地形定位和定量玻璃疣负荷比较方面进行分析。共41例54只眼诊断为RPD的患者被纳入本研究。IR图像上RPD病灶平均数为320±44.62个，而面内SDD病灶平均数为127±26.02个（P<0.001）。大多数RPD病变与SDD病变不重叠，并且位于大于30微米的距离（92%）。与RPD重叠的SDD病变占总病变的2.91±0.87%，与对照组RPD病变重叠的SDD病变占总病变的1.73±0.68%（P<0.05）。距离最近的RPD病灶1-3像素的SDD病灶占总SDD病灶的百分比为5.08±1.40%，而距离最近的对照RPD病灶1-3像素的SDD病灶占总SDD病灶的百分比为3.33±1.07%（P<0.05）。该研究发现，与正面SD-OCT上的SDD病变相比，IR上的RPD病变明显更多，并且发现大多数SDD（>90%的病变）距离最近的RPD大于30微米。总之，我们的研究结果表明，RPD和SDD是两个实体，只是偶尔地形相关，这表明在他们的发展的某个阶段，他们可能是病理相关的。
To evaluate the quantitative and topographic relationship between reticular pseudodrusen (RPD) on infrared reflectance (IR) and subretinal drusenoid deposits (SDD) on en face volumetric spectral-domain optical coherence tomography (SD-OCT). RPD were marked on IR images by a masked observer. SDD were visualized on en-face sections of SD-OCT below the external limiting membrane and identified by a semi-automated technique. Control RPD lesions were generated in a random distribution for each IR image. Binary maps of control and experimental RPD and SDD were merged and analyzed in terms of topographic localization and quantitative drusen load comparison. A total of 54 eyes of 41 patients diagnosed with RPD were included in this study. The average number of RPD lesions on IR images was 320±44.62 compared to 127±26.02 SDD lesions on en-face (P<0.001). The majority of RPD lesions did not overlap with SDD lesions, and were located greater than 30 microns away (92%). The percentage of total SDD lesions overlapping RPD was 2.91±0.87% compared to 1.73±0.68% overlapping control RPD lesions (P<0.05). The percentage of total SDD lesions between 1-3 pixels of the nearest RPD lesion was 5.08±1.40% compared to 3.33±1.07% between 1-3 pixels of the nearest control RPD lesion (P<0.05). This study identified significantly more RPD lesions on IR compared with SDD lesions on en-face SD-OCT and found that a large majority of SDD (>90% of lesions) were greater than 30 microns away from the nearest RPD. Together, our findings indicate that RPD and SDD are two entities that are only occasionally topographically associated, suggesting that at some stage in their development, they may be pathologically related.