Obesity and quality of life: Mediating effects of pain and comorbidities
Obesity and quality of life: Mediating effects of pain and comorbidities
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DOI：
10.1038/oby.2003.33
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发表时间：
2003-02-01
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影响因子：
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通讯作者：
Fontaine, KR
中科院分区：
文献类型：
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作者：
Heo, M;Allison, DB;Fontaine, KR
目的：估计体重指数（BMI）和健康相关的生活质量（HRQL）之间的关联，并检查是否关节疼痛和肥胖相关的合并症介导的BMI-HRQL association.Research方法和程序：基于人口的调查数据从1999年的行为危险因素监测调查。成年人（N = 155，989）根据BMI分类为体重过轻（< 18.5 kg/m（2）），理想重量（18.5至24.9公斤/平方米），超重（25至29.9 kg/m2）、肥胖I级（30至34.9 kg/m2）、肥胖II级（35至39.9 kg/m2）和肥胖III级（大于或等于40 kg/m2）。数据包括一般健康状况，不健康的日子在过去的30年中所造成的身体问题和精神问题，总不健康的日子在过去的30.Results：调整后的年龄，性别，种族，吸烟，教育，和收入，我们观察到J形的BMI和HRQL之间的关联。与理想体重的成年人相比，体重不足、超重和肥胖的I、II和III级成年人[比值比（OR）分别为1.57、1.19、1.95、2.72和4.36]更有可能报告一般健康状况一般/较差。对于由身体问题引起的不健康日，相应的OR值分别为1.51、1.15、1.66、2.27和3.61（p < 0.001）。由心理问题引起的不健康日OR值分别为1.35、1.14、1.43、1.57和2.25（p < 0.001）。对于总的不健康天数，相应的OR值分别为1.27、1.09、1.37、1.73和2.46（p < 0.01）。将关节疼痛和肥胖相关的合并症加入模型中减弱了BMI与HRQL的相关性。讨论：BMI与HRQL指数之间的相关性呈J形。关节疼痛和合并症可能介导BMI-HRQL相关性。
Objective: To estimate the association between body mass index (BMI) and health-related quality of life (HRQL) and examine whether joint pain and obesity-related comorbidities mediate the BMI-HRQL association.Research Methods and Procedures: Population-based survey data from the 1999 Behavioral Risk Factor Surveillance Survey. Adults (N = 155,989) were classified according to BMI as underweight (< 18.5 kg/m(2)), desirable weight (18.5 to 24.9 kg/m(2)), overweight (25 to 29.9 kg/m(2)), obese class I (30 to 34.9 kg/m(2)), obese class II (35 to 39.9 kg/m(2)), and obese class III ( greater than or equal to40 kg/m(2)). Data including general health status, unhealthy days in the past 30 caused by physical problems and mental problems, and total unhealthy days in the past 30 were collected.Results: After adjusting for age, sex, race, smoking, education, and income, we observed J-shaped associations between BMI and HRQL. Compared with desirable weight adults, underweight, overweight, and obesity classes I, II, and III adults [odds ratio (OR) = 1.57, 1.19, 1.95, 2.72, and 4.36, respectively] were significantly (p < 0.001) more likely to report fair/poor general health status. For unhealthy days caused by physical problems, the corresponding ORs were 1.51, 1.15, 1.66, 2.27, and 3.61 (p < 0.001). For unhealthy days caused by mental problems, the ORs were 1.35, 1.14 1.43, 1.57, and 2.25 (p < 0.001). For total unhealthy days, the corresponding ORs were 1.27, 1.09, 1.37, 1.73, and 2.46 (p < 0.01). Adding joint pain and obesity-related comorbidities into models attenuated BMI-HRQL associations.Discussion: Associations between BMI and HRQL indices were J-shaped. Joint pain and comorbidities may mediate BMI-HRQL associations.