A macroscopic description of lipid bilayer phase transitions of mixed-chain phosphatidylcholines: chain-length and chain-asymmetry dependence.
A macroscopic description of lipid bilayer phase transitions of mixed-chain phosphatidylcholines: chain-length and chain-asymmetry dependence.
复制标题
混合链磷脂酰胆碱脂质双层相变的宏观描述：链长和链不对称依赖性。
DOI：
10.1016/s0006-3495(01)76011-0
复制
发表时间：
2001
影响因子：
3.4
通讯作者：
Biltonen,RL
中科院分区：
文献类型：
--
作者：
Chen,L;Johnson,ML;Biltonen,RL
提出了一个宏观模型来定量描述脂质双层凝胶到流体的相变。在该模型中，脂双层的吉布斯势用一个单序参数q表示，即平均链取向序参数。吉布斯势是基于分子平均场和链间和链内相互作用的统计力学计算。链长和链不对称性被纳入吉布斯潜力，使一个方程提供了一个准确的描述混合链磷脂酰胆碱的一个单一的类。在这项工作中，两个一般类的脂质进行了研究：脂质双层的部分或noninterdigitated凝胶相，和双层的混合interdigitated凝胶相。通过拟合磷脂酰胆碱的相变温度和相变焓数据，得到了模型参数。所提出的模型提供了估计的转变温度和焓，货车的能量，数ofgauchebonds，链取向序参数，键旋转和排除体积熵，实现与现有的数据与各种技术获得的极好的协议。
A macroscopic model is presented to quantitatively describe lipid bilayer gel to fluid phase transitions. In this model, the Gibbs potential of the lipid bilayer is expressed in terms of a single order parameterq,the average chain orientational order parameter. The Gibbs potential is based on molecular mean-field and statistical mechanical calculations of inter and intrachain interactions. Chain-length and chain-asymmetry are incorporated into the Gibbs potential so that one equation provides an accurate description of mixed-chain phosphatidylcholines of a single class. Two general classes of lipids are studied in this work: lipid bilayers of partially or noninterdigitated gel phases, and bilayers of mixed interdigitated gel phases. The model parameters are obtained by fitting the transition temperature and enthalpy data of phosphatidylcholines to the model. The proposed model provides estimates for the transition temperature and enthalpy, van der Waals energy, number ofgauchebonds, chain orientational order parameter, and bond rotational and excluded volume entropies, achieving excellent agreement with existing data obtained with various techniques.