3-DIMENSIONAL STRUCTURE OF A PYRIDOXAL-PHOSPHATE-DEPENDENT ENZYME, MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE
3-DIMENSIONAL STRUCTURE OF A PYRIDOXAL-PHOSPHATE-DEPENDENT ENZYME, MITOCHONDRIAL ASPARTATE-AMINOTRANSFERASE
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DOI：
10.1073/pnas.77.5.2559
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
JANSONIUS, JN
中科院分区：
文献类型：
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作者：
FORD, GC;EICHELE, G;JANSONIUS, JN
x射线衍射研究到2.8-.ANG。分辨率得到了[鸡]线粒体天冬氨酸转氨酶的三维结构，这是一种同源的α。2二聚体(MW = 2。45000)。亚基具有丰富的二级结构，包含2个结构域，其中一个结构域锚定辅酶pyridoxal 5' -phosphate。每个活性位点位于亚基之间，由它们两个的残基组成。
X-ray diffraction studies to 2.8-.ANG. resolution have yielded the 3-dimensional structure of [chicken] mitochondrial aspartate aminotransferase, an isologous .alpha.2 dimer (MW = 2 .times. 45,000). The subunits are rich in secondary structure and contain 2 domains, one of which anchors the coenzyme, pyridoxal 5''-phosphate. Each active site lies between the subunits and is composed of residues from both of them.