Influence of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous herpes simplex virus type 1 infection in hairless mice with 2',3'-di-O-acetyl-9-beta-D-arabinofuranosyladenine and 5'-O-valeryl-9-beta-D-arabinofuranosyladenine.
Influence of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous herpes simplex virus type 1 infection in hairless mice with 2',3'-di-O-acetyl-9-beta-D-arabinofuranosyladenine and 5'-O-valeryl-9-beta-D-arabinofuranosyladenine.
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1-十二烷基氮杂环庚烷-2-酮（Azone）对 2,3-di-O-乙酰基-9-β-D-阿拉伯呋喃糖腺嘌呤和 5 局部治疗无毛小鼠皮肤单纯疱疹病毒 1 型感染的影响
DOI：
10.1002/jps.2600741105
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发表时间：
1985
影响因子：
3.8
通讯作者：
Vaidyanathan,R
中科院分区：
文献类型：
--
作者：
Shannon,WM;Westbrook,L;Higuchi,WI;Sugibayashi,K;Baker,DC;Kumar,SD;Fox,JL;Flynn,GL;Ho,NF;Vaidyanathan,R
用2种9-β-D-阿拉伯呋喃糖基腺嘌呤(Ara-A)(1)的两种酯前药，对最近开发的物理模型在局部治疗无毛小鼠单纯疱疹病毒1型引起的皮肤感染中的预测价值进行了测试。试验是用2‘，3’-二-O-乙酰基-阿拉伯-A(4)和5‘-O-戊基-阿拉伯-A(3)外用或不加15%氮酮(氮酮)进行的。除了体内研究外，还进行了体外扩散池实验，对无毛小鼠的全层皮肤进行了体外扩散实验，以确定2的渗透促进作用。正如之前观察到的，在这些体外实验中，2能够诱导非常大的(100-1000倍)通量增强。与基于物理模型研究的预测一致，不含2的配方3和4对1型单纯疱疹病毒感染的发病机制影响很小或没有影响；当配方中存在2时，3和4均具有与物理模型预测一致的显著治疗效果。普罗沙星4和2在预防病毒引起的损伤和所有动物的存活方面特别有效。在该模型体系中，阿昔洛韦+2也得到了类似的结果。
The predictive value of a recently developed physical model was tested in the topical treatment of cutaneous infections caused by herpes simplex virus type 1 in hairless mice with two ester prodrugs of 9-β-D-arabinofuranosyladenine (ara-A) (1). The tests were conducted with 2′,3′-di-O-acetyl-ara-A (4) and 5′-O-valeryl-ara-A (3) topically applied with and without 15% 1-dodecylazacycloheptan-2-one (2) (Azone), a percutaneous penetration enhancer. In addition to the in vivo studies, in vitro diffusion cell experiments with excised, full-thickness skin from hairless mice were conducted to determine the penetration enhancement effects of2. As previously observed,2was able to induce remarkably large (100- to 1000-fold) flux enhancements in these in vitro experiments. Consistent with predictions based on the physical model studies, formulations of3and4without2had little or no influence on the pathogenesis of the herpes simplex virus type 1 infections; when2was present in the formulations, both3and4had dramatic therapeutic effects consistent with the predictions made with the physical model. Prodrug4with2was especially efficacious in the prevention of virus-induced lesions and in the survival of all animals. Similar results were obtained with acyclovir plus2in this model system.
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ESR- 和 CD-Spektren von pH-abhängigen Konformationsisomeren des Hämoglobin(III)
影响因子：
5.4
作者：
K. Gersonde;A. Wollmer
通讯作者：
A. Wollmer
淡水鱼 Piraracú Arapaima gigas 的红细胞中的肌醇五磷酸盐。
影响因子：
6.1
作者：
R. Isaacks;H. D. Kim;G. R. Bartlett;D. Harkness
通讯作者：
D. Harkness
溶液中摇蚊高铁血红蛋白的分子特性。
DOI：
10.1111/j.1432-1033.1967.tb19510.x
发表时间：
1967
期刊：
European journal of biochemistry
影响因子：
--
作者：
J. Behlke;W. Scheler
通讯作者：
W. Scheler
DOI：
10.1111/j.1432-1033.1972.tb01683.x
发表时间：
1972
期刊：
European journal of biochemistry
影响因子：
--
作者：
K. Gersonde;H. Sick;A. Wollmer;G. Buse
通讯作者：
G. Buse
人血红蛋白的玻尔效应
影响因子：
13.8
作者：
J. Kilmartin
通讯作者：
J. Kilmartin