Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.
Bile acids and sphingosine-1-phosphate receptor 2 in hepatic lipid metabolism.
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DOI：
10.1016/j.apsb.2014.12.009
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Zhou H
中科院分区：
文献类型：
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作者：
Kwong E;Li Y;Hylemon PB;Zhou H
肝脏是参与脂质代谢的中心器官。血脂异常及其相关疾病，包括非酒精性脂肪性肝病（NAFLD）、肥胖症和其他代谢性疾病，由于其在人群中的患病率不断增加，因此越来越受到公众健康关注。除了在胆固醇体内平衡和营养吸收方面的良好功能外，胆汁酸也是重要的代谢调节剂，并通过激活特异性核受体、G蛋白偶联受体和多种信号传导途径作为信号激素发挥作用。近年来研究发现，结合胆汁酸（CBA）通过鞘氨醇1磷酸受体2（S1 PR 2）激活细胞外调节蛋白激酶（ERK 1/2）和蛋白激酶B（AKT）信号通路。CBA诱导的S1 PR 2激活是鞘氨醇激酶2（SphK 2）和肝脏基因表达的关键调节因子。本文重点介绍与胆汁酸/S1 PR 2介导的信号通路在调节肝脏脂质代谢中的作用相关的最新发现。本文综述了胆汁酸/S1 PR 2介导的信号通路在调节肝脏脂质代谢中的作用。
The liver is the central organ involved in lipid metabolism. Dyslipidemia and its related disorders, including non-alcoholic fatty liver disease (NAFLD), obesity and other metabolic diseases, are of increasing public health concern due to their increasing prevalence in the population. Besides their well-characterized functions in cholesterol homoeostasis and nutrient absorption, bile acids are also important metabolic regulators and function as signaling hormones by activating specific nuclear receptors, G-protein coupled receptors, and multiple signaling pathways. Recent studies identified a new signaling pathway by which conjugated bile acids (CBA) activate the extracellular regulated protein kinases (ERK1/2) and protein kinase B (AKT) signaling pathway via sphingosine-1-phosphate receptor 2 (S1PR2). CBA-induced activation of S1PR2 is a key regulator of sphingosine kinase 2 (SphK2) and hepatic gene expression. This review focuses on recent findings related to the role of bile acids/S1PR2-mediated signaling pathways in regulating hepatic lipid metabolism. This review focuses on recent findings related to the role of bile acids/S1PR2-mediated signaling pathways in regulating hepatic lipid metabolism.