NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age
NMR imaging estimates of muscle volume and intramuscular fat infiltration in the thigh: variations with muscle, gender, and age
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DOI：
10.1007/s11357-015-9798-5
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发表时间：
2015-06-01
期刊：
影响因子：
--
通讯作者：
Carlier, Pierre G.
中科院分区：
文献类型：
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作者：
Hogrel, Jean-Yves;Barnouin, Yoann;Carlier, Pierre G.
由于肌肉质量与身体表现和自主性有关，因此在衰老过程中肌肉质量与跟踪特别相关。这项工作的目的是使用磁共振成像（MRI）评估大量年轻和老年健康个体大腿所有肌肉的肌肉体积（MV）和肌内脂肪（IMF），以测试性别和年龄对MV和IMF的影响，并确定估计MV和IMF的最佳代表切片。该研究招募了105名健康的年轻（范围20-30岁）和老年（范围70-80岁）受试者。使用三维三点狄克逊质子密度加权梯度回波序列沿股骨长度采集沿着MRI扫描。从所有切片估计MV和IMF。评估年龄和性别对MV和IMF的影响。为了减少分析过程，在每个肌肉的不同股骨水平使用单个切片建立MV和IMF的预测方程。男性和女性的MV均随年龄增长而降低，尤其是股四头肌。随着男性的老龄化，IMF在很大程度上增加，女性的增加程度较小。随增龄，肌肉的MV值降低，IMF值升高，但各肌肉的变化规律不同。提供并验证了从单个切片预测MV和IMF的预测方程。这项研究是第一项提供大量年轻和老年健康受试者大腿所有肌肉的肌肉体积和肌内脂肪浸润的研究。
Muscle mass is particularly relevant to follow during aging, owing to its link with physical performance and autonomy. The objectives of this work were to assess muscle volume (MV) and intramuscular fat (IMF) for all the muscles of the thigh in a large population of young and elderly healthy individuals using magnetic resonance imaging (MRI) to test the effect of gender and age on MV and IMF and to determine the best representative slice for the estimation of MV and IMF. The study enrolled 105 healthy young (range 20-30 years) and older (range 70-80 years) subjects. MRI scans were acquired along the femur length using a three-dimension three-point Dixon proton density-weighted gradient echo sequence. MV and IMF were estimated from all the slices. The effects of age and gender on MV and IMF were assessed. Predictive equations for MV and IMF were established using a single slice at various femur levels for each muscle in order to reduce the analysis process. MV was decreased with aging in both genders, particularly in the quadriceps femoris. IMF was largely increased with aging in men and, to a lesser extent, in women. Percentages of MV decrease and IMF increase with aging varied according to the muscle. Predictive equations to predict MV and IMF from single slices are provided and were validated. This study is the first one to provide muscle volume and intramuscular fat infiltration in all the muscles of the thigh in a large population of young and elderly healthy subjects.