THE SUPPRESSION OF AGE-RELATED ACCUMULATION OF LIPID PEROXIDES IN RAT-BRAIN BY ADMINISTRATION OF ROOIBOS TEA (ASPALATHUS-LINEARIS)
THE SUPPRESSION OF AGE-RELATED ACCUMULATION OF LIPID PEROXIDES IN RAT-BRAIN BY ADMINISTRATION OF ROOIBOS TEA (ASPALATHUS-LINEARIS)
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DOI：
10.1016/0304-3940(95)11853-o
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发表时间：
1995-08-18
影响因子：
2.5
通讯作者：
KUWABARA, M
中科院分区：
文献类型：
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作者：
INANAMI, O;ASANUMA, T;KUWABARA, M
用硫代巴比妥酸反应（TBA）和磁共振成像（MRI）方法研究了路易波士茶（RT）对衰老引起的中枢神经系统（CNS）损伤的保护作用。从3月龄Wistar雌性大鼠开始自由饮水，连续饮水21个月，24月龄大鼠额叶、枕叶、海马和小脑TBA反应物质（TBARS）含量显著高于青年大鼠然而，在RT给药的老年大鼠中没有观察到TBARS的显著增加。当拍摄24月龄大鼠和未接受RT以及5周龄大鼠的大脑MR图像时，在未接受RT的老年大鼠的MR图像中观察到大脑皮层、海马和小脑中的信号强度降低，而在接受RT的24月龄大鼠的相同区域的MR图像中观察到信号强度几乎没有变化，其图像与年轻大鼠的图像相似。这些观察结果表明：（1）脑中与年龄相关的脂质过氧化物蓄积与MRI观察到的形态学变化密切相关，（2）长期RT给药可防止大鼠脑多个区域中与年龄相关的脂质过氧化物蓄积。
The protective effects of Rooibos tea (RT), Aspalathus linearis, against damage to the central nervous system (CNS) accompanying aging were examined by both the thiobarbituric acid reaction (TBA) and magnetic resonance imaging (MRI) methods in brains of chronically RT-treated rats. Ad libitum administration of RT was begun with 3-month-old Wistar female rats and continued for 21 months, The contents of TBA reactive substances (TBARS) in the frontal cortex, occipital cortex, hippocampus and cerebellum in 24-month-old rats after administration with water were significantly higher than those in young rats (5 weeks old), However, no significant increase of TBARS was observed in RT-administered aged rats. When MR images of the brains of 24-month-old rats with and without RT as well as 5-week-old rats were taken, a decrease of the signal intensity was observed in the cerebral cortex, hippocampus and cerebellum in MR images of aged rats without RT, whereas little change of the signal intensity was observed in MR images of the same regions of 24-month-old rats treated with RT, whose images were similar to those of young rats. These observations suggested that (1) the age-related accumulation of lipid peroxides in the brain was closely related to the morphological changes observed by MRI, and (2) chronic RT-administration prevented age-related accumulation of lipid peroxides in several regions of rat brain.