Non-carcinogenicity of capsaicinoids in B6C3F1 mice
Non-carcinogenicity of capsaicinoids in B6C3F1 mice
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DOI：
10.1016/s0278-6915(98)00077-5
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发表时间：
1998-12-01
影响因子：
4.3
通讯作者：
Izumi, K
中科院分区：
文献类型：
--
作者：
Akagi, A;Sano, N;Izumi, K
用B6C3F(1)小鼠研究了辣椒素混合物(64.5%辣椒素和32.6%二氢辣椒素)的致癌性。在一项为期13周的毒性研究中，观察到服用1%辣椒素的男性有肾毒性。接下来，在粉末状饲料中分别给予0.025、0.025、0.083或0.25%辣椒素的小鼠，雌雄各半，持续79周，并在83周处死。由于辣椒素的刺激性，所有辣椒素处理组的小鼠，特别是雌性小鼠的摄食量都减少了，雌性小鼠的体重增加受到了明显的抑制。高剂量组荷瘤女性数显著低于对照组，且男女肝细胞肿瘤发生率与辣椒素剂量呈负相关(Cochran-Armitage趋势检验)。0.025%和0.25%辣椒素处理的雄性小鼠各有一只发生肾细胞腺瘤。治疗组和对照组其他肿瘤的发生率相似。因此，本研究表明，辣椒素的混合物对B6C3F(1)小鼠没有致癌作用。(C)1998爱思唯尔科学有限公司。保留所有权利。
The carcinogenicity of a mixture of capsaicinoids (64.5% capsaicin and 32.6% dihydrocapsaicin) was examined in B6C3F(1) mice. In a 13-week toxicity study, renal toxicity was observed in 1% capsaicinoid-treated males. Next, groups of 50 mice of each sex were given 0, 0.025, 0.083 or 0.25% capsaicinoids in powdered diet for 79 weeks and killed in week 83. Food intake was reduced in mice of all capsaicinoid-treated groups, especially females, because of the pungency of capsaicinoids, and inhibition of body weight gain was apparent in females. The numbers of tumour-bearing females in the high-dose groups were significantly lower than that in the controls, and the incidences of hepatocellular neoplasms in both sexes were negatively correlated with the dose of capsaicinoids (Cochran-Armitage trend test). Renal cell adenomas developed in one mouse each of 0.025 and 0.25% capsaicinoid-treated males. The incidences of other tumours were similar in the treated and control groups. Thus, the present study indicated that a mixture of capsaicinoids is not carcinogenic in B6C3F(1) mice. (C) 1998 Elsevier Science Ltd. All rights reserved.