Trends in receiving chemotherapy for advanced cancer patients at the end of life.
Trends in receiving chemotherapy for advanced cancer patients at the end of life.
复制标题
DOI：
10.1186/s12904-015-0001-7
复制
发表时间：
2015
影响因子：
3.1
通讯作者：
Lee S
中科院分区：
文献类型：
--
作者：
Lee HS;Chun KH;Moon D;Yeon HK;Lee S;Lee S
随着新型高效抗癌治疗剂的开发，晚期癌症患者化疗的使用有所增加。在目前的研究中，我们分析了在生命结束时接受化疗的患者的10年趋势。我们回顾性分析了2000年、2005年和2010年在同一家医疗机构死亡的晚期癌症患者的死亡率数据。每年评估患者在生命结束时接受姑息性化疗的趋势。此外，进行Logistic回归分析，以确定与接受化疗相关的因素。我们分析了2,345名死于癌症的患者的记录。与死亡时肿瘤有反应的患者相比，肿瘤有反应的患者接受化疗的可能性更小。与生命结束时< 65岁的患者相比，≥ 65岁的患者接受化疗的可能性较小。然而，与2005年（32.7%）和2000年（25.7%）相比，2010年（44.2%）在生命最后一个月接受化疗的老年患者比例有所增加。与2000年相比，在生命的最后1个月内接受化疗的可能性在2005年（比值比[OR]，2.05; 95%置信区间[CI]，1.60-2.62）和2010年（OR，4.42; 95% CI，3.51-5.57）增加。从2000年到2005年到2010年，临终时接受化疗的患者比例连续增加。医生应该考虑是否在生命结束时继续化疗。
The use of chemotherapy in advanced cancer patients has increased with the development of novel, high-efficacy anticancer therapeutic agents. In the current study, we analyzed the 10-year trends in patients receiving chemotherapy at the end of life. We retrospectively reviewed mortality data for advanced cancer patients who died in 2000, 2005, and 2010 at a single institution. The trends of receiving palliative chemotherapy at the end of life were assessed for each year. In addition, logistic regression analysis was performed to determine the factors associated with receiving chemotherapy. We analyzed the records of 2,345 patients who died of cancer. Patients with less responsive tumors were less likely to receive chemotherapy than patients with responsive tumors at the time of death. Patients who were ≥ 65 years were less likely to receive chemotherapy compared with patients who were < 65 years at the end of life. However, the proportion of older patients receiving chemotherapy in the last month of life increased in 2010 (44.2%) compared with 2005 (32.7%) and 2000 (25.7%). Compared with the year 2000, the likelihood of receiving chemotherapy during the last 1 month of life increased in 2005 (odds ratio [OR], 2.05; 95% confidence interval [CI], 1.60–2.62) and 2010 (OR, 4.42; 95% CI, 3.51–5.57). The proportion of patients receiving chemotherapy at the end of life increased successively from 2000 to 2005 to 2010. Physicians should consider whether to continue chemotherapy at the end of life.
登录
查看更多内容
影响因子：
2.4
作者：
Keam, Bhumsuk;Oh, Do-Youn;Heo, Dae Seog
通讯作者：
Heo, Dae Seog
影响因子：
3.8
作者：
Bookwala, J;Coppola, KM;Smucker, WD
通讯作者：
Smucker, WD
影响因子：
50.5
作者：
Tang, S. T.;Wu, S. -C.;Liu, T. -W.
通讯作者：
Liu, T. -W.
影响因子：
50.5
作者：
Kao, S.;Shafiq, J.;Adams, D.
通讯作者：
Adams, D.
影响因子：
3.6
作者：
Braga, Sofia;Miranda, Ana;Moreira, Antonio
通讯作者：
Moreira, Antonio