Lack of Association between COX-2 Staining Level and Biochemical Recurrence Following Salvage Radiation Therapy for Recurrent Prostate Cancer.
Lack of Association between COX-2 Staining Level and Biochemical Recurrence Following Salvage Radiation Therapy for Recurrent Prostate Cancer.
复制标题
COX-2 染色水平与复发性前列腺癌挽救性放射治疗后生化复发之间缺乏关联。
DOI：
10.1007/s13566-013-0099-2
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Buskirk,StevenJ
中科院分区：
文献类型：
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作者：
Heckman,MichaelG;Tzou,KatherineS;Parker,AlexanderS;Pisansky,ThomasM;Schild,StevenE;Hilton,TracyW;Patel,VivekN;Pelaez,Liset;Khor,LiYan;Peterson,JenniferL;Daugherty,LarryC;Vallow,LauraA;Pollack,Alan;Buskirk,StevenJ
ObjectiveThe ability to predict which men will experience biochemical recurrence (BCR) after salvage radiation therapy (SRT) for recurrent prostate cancer following radical prostatectomy has potential for improvement. Cyclooxygenase-2 (COX-2) overexpression has previously correlated with poor clinical outcomes following primary treatment for prostate cancer; however, its predictive ability in the specific setting of SRT has not been examined to date. This study evaluated the association between COX-2 staining intensity and BCR following SRT for recurrent prostate cancer.MethodsWe utilized a cohort of 151 patients who underwent SRT between July 1987 and July 2003. COX-2 staining intensity in primary tumor samples was detected using monoclonal antibodies and quantified using a computer-assisted method. The association between COX-2 staining intensity and BCR was evaluated using multivariable Cox regression models.ResultsWhen examining COX-2 staining level as three-level categorical variable (low, moderate, high) based on approximate sample tertiles, there was no evidence of an association with BCR (P= 0.18). More specifically, in comparison to patients with low staining intensity, there was no significant difference in risk of BCR for moderate (relative risk [RR], 1.17;P= 0.56) or high (RR, 0.72;P= 0.22) COX-2 staining intensity patients. This lack of association was also observed when considering COX-2 staining intensity as a continuous variable (RR, 0.83;P= 0.15).ConclusionOur results indicate that COX-2 staining intensity is likely of little use in discriminating prognosis of SRT. It appears that the search for prognostic factors associated with BCR should continue elsewhere in order to further enhance patient selection for SRT.
