Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults.
Trauma-associated anterior cingulate connectivity during reward learning predicts affective and anxiety states in young adults.
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DOI：
10.1017/s0033291718002520
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发表时间：
2019-08
影响因子：
6.9
通讯作者：
Phillips ML
中科院分区：
文献类型：
--
作者：
Eckstrand KL;Hanford LC;Bertocci MA;Chase HW;Greenberg T;Lockovich J;Stiffler R;Aslam HA;Graur S;Bebko G;Forbes EE;Phillips ML
创伤暴露与抑郁和焦虑的发展有关;然而，有些人对这些创伤相关的影响具有弹性。区分创伤后负面影响和复原力发展的潜在机制对于制定有效的干预措施至关重要。创伤对负面情绪产生影响的途径之一是奖励学习网络。在这项研究中，我们研究了年轻人的终身创伤，奖励学习网络功能和情绪状态之间的关系。111名年轻人自我报告创伤和情绪状态，并在金钱奖励任务中接受功能性磁共振成像。在奖励预测错误（RPE）过程中，分析了创伤相关的神经激活和功能连接。创伤相关的神经功能和情感和焦虑症状之间的关系进行了检查。创伤事件的数量与更大的腹侧前扣带皮层（vACC）激活，以及较低的vACC连接与右颞叶，额极，下顶叶和颞顶区域，在RPE。与额顶叶区域的创伤相关vACC连接性较低，涉及调节和决策过程，与情感和焦虑症状加剧相关;与岛状区域的vACC连接性较低，涉及内感受，与情感和焦虑症状较低相关。在一个年轻的成年人样本中，有两条途径将创伤对奖励学习网络的影响与较高的消极情感和焦虑症状联系起来。vACC与参与决策和自我参照过程的区域之间的断开可能分别反映了异常的调节机制，但适当的自我关注机制，赋予了对消极情感和焦虑症状的恢复力的风险。
Trauma exposure is associated with development of depression and anxiety; yet, some individuals are resilient to these trauma-associated effects. Differentiating mechanisms underlying development of negative affect and resilience following trauma is critical for developing effective interventions. One pathway through which trauma could exert its effects on negative affect is reward-learning networks. In this study, we examined relationships among lifetime trauma, reward-learning network function, and emotional states in young adults. One hundred eleven young adults self-reported trauma and emotional states and underwent functional magnetic resonance imaging during a monetary reward task. Trauma-associated neural activation and functional connectivity were analyzed during reward prediction error (RPE). Relationships between trauma-associated neural functioning and affective and anxiety symptoms were examined. Number of traumatic events was associated with greater ventral anterior cingulate cortex (vACC) activation, and lower vACC connectivity with the right insula, frontopolar, inferior parietal, and temporoparietal regions, during RPE. Lower trauma-associated vACC connectivity with frontoparietal regions implicated in regulatory and decision-making processes was associated with heightened affective and anxiety symptoms; lower vACC connectivity with insular regions implicated in interoception was associated with lower affective and anxiety symptoms. In a young adult sample, two pathways linked the impact of trauma on reward-learning networks with higher v. lower negative affective and anxiety symptoms. The disconnection between vACC and regions implicated in decision-making and self-referential processes may reflect aberrant regulatory but appropriate self-focused mechanisms, respectively, conferring risk for v. resilience against negative affective and anxiety symptoms.