Areal extent quantification of functional representations using intrinsic signal optical imaging
Areal extent quantification of functional representations using intrinsic signal optical imaging
复制标题
DOI：
10.1016/0165-0270(96)00056-8
复制
发表时间：
1996-09-01
影响因子：
3
通讯作者：
Frostig, RD
中科院分区：
文献类型：
--
作者：
ChenBee, CH;Kwon, MC;Frostig, RD
一个重要的参数，经常调查的表征皮层功能组织是功能模块的面积范围。因为它允许可视化的功能模块具有高的空间分辨率，在一个非侵入性的方式对皮层，内在信号光学成像（ISI）可以用于这些面积范围的量化。本文介绍了使用面积范围量化的归一化阈值分析的成年大鼠的初级躯体感觉皮层的单须功能表征的客观评估。由于面积范围量化的成功取决于ISI的能力，以允许可视化的皮质表示与最小的刺激依赖的血管表示，这是ISI常见的，本文还介绍了进一步发展的心房内分析可视化，以尽量减少这些血管表示。这两种分析都讨论了它们的优点以及它们固有的局限性。
An important parameter often investigated in the characterization of cortical functional organization is the areal extent of functional modules. Because it allows the visualization of functional modules with high spatial resolution in a noninvasive way to the cortex, intrinsic signal optical imaging (ISI) can be employed for the quantification of these areal extents. The present paper describes the use of the normalized threshold analysis of areal extent quantification for the objective assessment of single-whisker functional representations in the primary somatosensory cortex of adult rats. As the success of areal extent quantification depends on the ability of ISI to allow visualization of cortical representations with minimal stimulus-dependent blood vessel representations, which are commonly encountered by ISI, the present paper also describes the further development of the intratrial analysis of visualization for minimizing these vessel representations. Both analyses are discussed with respect to their advantages as well as their inherent limitations.