Efcts of chronic ethanol feeding on serum lipoprotein metabolism in the rat.
Efcts of chronic ethanol feeding on serum lipoprotein metabolism in the rat.
复制标题
慢性乙醇喂养对大鼠血清脂蛋白代谢的影响。
DOI：
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发表时间：
1970
影响因子：
15.9
通讯作者：
C. Lieber
中科院分区：
文献类型：
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作者：
E. Baraona;C. Lieber
在大鼠中，发现慢性乙醇喂养可增强餐后高脂血症，并增加膳食棕榈酸-（3）H和静脉注射L-赖氨酸-（14）C掺入血清脂蛋白的量。脂质和蛋白质总量、标记和比活性的增加主要发生在d < 1.019的脂蛋白组分。脂肪吸收和注射乳糜微粒的清除率不受乙醇喂养的影响。用Triton阻断脂蛋白和乳糜微粒清除并不能阻止乙醇对血脂的作用，这表明乙醇的作用不太可能是由于循环中脂质的清除缺陷。乙醇增强了乳糜微粒脂肪酸与新合成的极低密度脂蛋白的结合，如在注射棕榈酸-（14）C/甘油-（3）H双标记乳糜微粒后，脂肪酸标记物在该组分脂质中的重现增加所示。这些结果表明，酒精性高脂血症是由于，至少部分是由于新合成的脂蛋白的增加。乙醇引起的高脂血症伴有肝脂肪变性。脂肪肝和脂蛋白血症的同时产生使得脂蛋白合成或分泌缺陷不太可能是酒精性脂肪肝发病的主要机制。
In rats, chronic ethanol feeding was found to enhance the postprandial hyperlipemia and to increase the incorporation of dietary palmitic acid-(3)H and intravenously injected L-lysine-(14)C into serum lipoproteins. The main increases of total amount, labeling, and specific activity of lipid and protein occurred in the d < 1.019 lipoprotein fraction. Fat absorption and the clearance of injected chylomicrons were not affected by ethanol feeding. Blocking of lipoprotein and chylomicron removal with Triton did not prevent the action of ethanol on serum lipids, indicating that the ethanol effect is not likely due to defective removal of lipids from the circulation. Ethanol enhanced the incorporation of chylomicron fatty acids into newly synthetized very low density lipoproteins, as shown by an increased reappearance of the fatty acid label into the lipids of this fraction after injection of palmitate-(14)C/glycerol-(3)H doubly labeled chylomicrons. These results indicate that alcoholic hyperlipemia is due, at least in part, to an increase in newly synthetized lipoproteins. The hyperlipemia produced by ethanol was accompanied by hepatic steatosis. The simultaneous production of fatty liver and hyperlipemia makes it unlikely that defective lipoprotein synthesis or secretion is a primary mechanism for the pathogenesis of the alcoholic fatty liver.