WHISKER-RELATED NEURONAL PATTERNS FAIL TO DEVELOP IN THE TRIGEMINAL BRAIN-STEM NUCLEI OF NMDAR1 KNOCKOUT MICE
WHISKER-RELATED NEURONAL PATTERNS FAIL TO DEVELOP IN THE TRIGEMINAL BRAIN-STEM NUCLEI OF NMDAR1 KNOCKOUT MICE
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DOI：
10.1016/0092-8674(94)90108-2
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发表时间：
1994-02-11
期刊：
影响因子：
64.5
通讯作者：
TONEGAWA, S
中科院分区：
文献类型：
--
作者：
LI, YQ;ERZURUMLU, RS;TONEGAWA, S
大脑的感觉通路通常从粗糙的有线网络发展到精确组织的系统。几项研究表明，神经活动依赖性机制，包括N-甲基-D-天冬氨酸（NMDA）受体，在这个细化过程。我们将基因靶向应用于NMDAR 1基因，并创建了缺乏功能性NMDA受体的突变小鼠。比较了突变小鼠及其正常同窝小鼠三叉神经核中胡须相关图案的发育。我们发现，在突变小鼠中，三叉神经轴突在脑干中的寻路、初始定位和粗糙的地形投影不受影响，但胡须特异性斑块未能形成。我们的研究结果提供了一个直接的演示参与的NMDA受体在哺乳动物大脑中的外周相关的神经模式的形成。
Sensory pathways of the brain generally develop from crudely wired networks to precisely organized systems. Several studies have implicated neural activity-dependent mechanisms, including N-methyl-D-aspartate (NMDA) receptors, in this refinement process. We applied the gene targeting to the NMDAR1 gene and created a mutant mouse that lacks functional NMDA receptors. The development of whisker-related patterns in the trigeminal nuclei of the mutant mice and their normal littermates was compared. We show that in the mutant mice pathfinding, initial targeting, and crude topographic projection of trigeminal axons in the brainstem are unaffected, but that whisker-specific patches fail to form. Our results provide a direct demonstration of the involvement of the NMDA receptor in the formation of periphery-related neural patterns in the mammalian brain.