Hepatocellular carcinoma (HCC) recurring 10 years after clearance of hepatitis B surface antigen and 20 years after resection of hepatitis B virus-related HCC
Hepatocellular carcinoma (HCC) recurring 10 years after clearance of hepatitis B surface antigen and 20 years after resection of hepatitis B virus-related HCC
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DOI：
10.1007/s10147-008-0785-z
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发表时间：
2008-12
影响因子：
3.3
通讯作者：
H. Shinkawa;T. Nakai;A. Tamori;Hiromu Tanaka;S. Takemura;K. Ohba;T. Uenishi;M. Ogawa;Satoshi Yamamoto;S. Hai;T. Ichikawa;Shintaro Kodai;K. Hirohashi;K. Wakasa;S. Kubo
中科院分区：
文献类型：
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作者：
H. Shinkawa;T. Nakai;A. Tamori;Hiromu Tanaka;S. Takemura;K. Ohba;T. Uenishi;M. Ogawa;Satoshi Yamamoto;S. Hai;T. Ichikawa;Shintaro Kodai;K. Hirohashi;K. Wakasa;S. Kubo
一名 62 岁男子自 1973 年以来一直接受慢性乙型肝炎 (HB) 随访。 1985 年，42 岁时查出肝细胞癌 (HCC)。当时血清HB表面抗原和抗HB包膜抗体呈阳性。进行了右肝叶切除术。 1995年，血清HB表面抗原自行清除，肝功能恢复正常。 2005年3月，62岁，左侧肝段发现直径1.5厘米的肝肿块。当时，他仅抗 HB 核心抗体血清呈阳性。诊断为复发性肝癌，并进行了部分肝切除术。通过巢式聚合酶链反应 (PCR) 在癌组织和非癌组织中检测到共价闭合环状 HBV DNA。盒式连接介导的 PCR 显示 HBV DNA 已整合到位于染色体 5p15 上的端粒酶逆转录酶基因中。
A 62-year-old man had been followed up for chronic hepatitis B (HB) since 1973. Hepatocellular carcinoma (HCC) was detected in 1985, at the age of 42 years. Serum HB surface antigen and anti-HB envelope antibody were positive at that time. A right hepatic lobectomy was performed. In 1995, serum HB surface antigen had cleared spontaneously and liver function had normalized. In March 2005, at the age of 62 years, a 1.5-cm diameter hepatic mass was detected in the left lateral segment. At that time, he was seropositive only for anti-HB core antibody. A diagnosis of recurrent HCC was made, and partial hepatectomy was performed. Covalently closed circular HBV DNA was detected in both cancerous and noncancerous tissues by nested polymerase chain reaction (PCR). Cassette-ligationmediated PCR showed that HBV DNA was integrated into the telomerase reverse transcriptase gene located on chromosome 5p15.