The Impact of Age on Mortality, Impairment, and Disability among Adults with Acute Traumatic Spinal Cord Injury
The Impact of Age on Mortality, Impairment, and Disability among Adults with Acute Traumatic Spinal Cord Injury
复制标题
DOI：
10.1089/neu.2009.0888
复制
发表时间：
2009-10-01
影响因子：
4.2
通讯作者：
Fehlings, Michael G.
中科院分区：
文献类型：
--
作者：
Furlan, Julio C.;Fehlings, Michael G.
鉴于年龄对创伤性脊髓损伤（SCI）患者死亡率、损伤和残疾的潜在影响，我们使用大型前瞻性累积临床数据库研究了这些问题。本研究包括所有入组第三次国家脊髓损伤研究（NASCIS 3）的患者。运动、感觉和疼痛结果采用NASCIS评分进行评估。使用功能独立性测量（Functional Independence Measure，简称FIA）评估功能结局。数据分析包括针对主要潜在混杂因素（即，性别、种族、格拉斯哥昏迷量表[GCS]评分、入院时的血液酒精浓度、药物方案、原因以及SCI的水平和严重程度）。在SCI后6周、6个月和1年，老年人（≥ 65岁）的死亡率明显高于年轻人（38.6%对3.1%; p
Given the potential effects of age on mortality, impairment, and disability among individuals with traumatic spinal cord injury (SCI), we examined these issues using a large, prospectively accrued clinical database. This study includes all patients who were enrolled in the Third National Spinal Cord Injury Study (NASCIS 3). Motor, sensory, and pain outcomes were assessed using NASCIS scores. Functional outcome was evaluated using the Functional Independence Measure (FIM). Data analyses included regression models adjusted for major potential confounders (i.e., sex, ethnicity, Glasgow Coma Scale [GCS] score, blood alcohol concentration on admission, drug protocol, cause, and level and severity of SCI). Mortality rates among older people (>= 65 years) were significantly greater than those of younger individuals at 6 weeks, at 6 months, and at 1 year following SCI (38.6% versus 3.1%; p