Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.
Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.
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DOI：
10.1111/acer.12964
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Li CS
中科院分区：
文献类型：
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作者：
Hu S;Zhang S;Chao HH;Krystal JH;Li CS
抑制控制的缺陷与酒精滥用密切相关。然而，文献并没有轻易区分饮酒问题和长期饮酒的影响。在这里，我们研究了饮酒年限和酒精使用障碍识别测试（AUDIT）评分如何影响非依赖饮酒者的大脑对抑制控制的反应。 57 名成年饮酒者和 57 名年龄和性别匹配的非饮酒者参加了一项为期 40 分钟的停止信号任务功能磁共振成像扫描。使用 SPM8 对数据进行预处理和建模。在回归模型中，我们对比了个体的走走停停的成功试验，并在小组分析中检查了反应抑制活动与 AUDIT 评分和饮酒年限的关系。我们通过对比饮酒者的区域激活和不饮酒者的年龄相关变化来明确使用持续时间的影响。在中介分析中，我们研究了区域活动如何中介饮酒问题和反应抑制之间的关系。较高的 AUDIT 评分与饮酒年数无关，与延长的停止信号反应时间 (SSRT) 以及小脑、丘脑、额叶和顶叶区域的反应减弱呈正相关，与饮酒年数无关。此外，丘脑、前扣带皮层和前补充运动区的活动显着介导 AUDIT 评分和 SSRT 之间的双向关联。饮酒持续时间与右侧额下回延伸至颞上回的激活减少相关，但在不饮酒者中未观察到与年龄相关的变化。结果区分了年轻成年非依赖饮酒者的饮酒问题和饮酒年限与抑制控制之间的关系。这些新发现扩展了酒精滥用的影像学文献，并可能对防止从社交饮酒升级为依赖饮酒的治疗产生影响。需要更多的研究来证实饮酒年限与年龄无关的神经相关性。
Deficits in inhibitory control have been widely implicated in alcohol misuse. However, the literature does not readily distinguish the effects of drinking problems and chronic alcohol use. Here, we examined how years of drinking and the Alcohol Use Disorders Identification Test (AUDIT) score each influences the cerebral responses to inhibitory control in non-dependent drinkers. Fifty-seven adult drinkers and 57 age and gender matched non-drinkers participated in one 40-minute fMRI scan of the stop signal task. Data were pre-processed and modeled using SPM8. In a regression model, we contrasted stop and go success trials for individuals and examined activities of response inhibition each in link with the AUDIT score and years of alcohol use in group analyses. We specified the effects of duration of use by contrasting regional activations of drinkers and age-related changes in non-drinkers. In mediation analyses, we investigated how regional activities mediate the relationship between drinking problems and response inhibition. Higher AUDIT score but not years of drinking was positively correlated with prolonged stop signal reaction time (SSRT) and diminished responses in the cerebellum, thalamus, frontal and parietal regions, independent of years of alcohol use. Further, activity of the thalamus, anterior cingulate cortex, and pre-supplementary motor area significantly mediates the association, bidirectionally, between the AUDIT score and SSRT. The duration of alcohol use was associated with decreased activation in the right inferior frontal gyrus extending to superior temporal gyrus, which was not observed for age-related changes in non-drinkers. The results distinguished the association of drinking problems and years of alcohol use to inhibitory control in young adult non-dependent drinkers. These new findings extend the imaging literature of alcohol misuse and may have implications for treatment to prevent the escalation from social to dependent drinking. More research is needed to confirm age-independent neural correlates of years of alcohol use.