SEX DIFFERENCE IN WHOLE-BODY ANDROGEN CONTENT IN RATS ON FETAL DAYS 18 AND 19 WITHOUT EVIDENCE THAT ANDROGEN PASSES FROM MALES TO FEMALES
SEX DIFFERENCE IN WHOLE-BODY ANDROGEN CONTENT IN RATS ON FETAL DAYS 18 AND 19 WITHOUT EVIDENCE THAT ANDROGEN PASSES FROM MALES TO FEMALES
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DOI：
10.1095/biolreprod44.5.747
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发表时间：
1991-05-01
影响因子：
3.6
通讯作者：
SLOB, AK
中科院分区：
文献类型：
--
作者：
BAUM, MJ;WOUTERSEN, PJA;SLOB, AK
雄性大鼠在胎仔第18天和第19天的全身雄激素含量（睾酮+5-α-二氢睾酮）显著高于雌性大鼠;在其他胎龄（包括第16、17、20和21天）和胎仔第22天分娩前，两种性别大鼠的雄激素含量相当。 这些结果部分证实了Weisz和Ward（Endocrinology 1980; 106：306-316）先前的数据，他们测量了来自大鼠胎儿的混合血浆中的睾酮，并表明雄激素仅在胎儿生命期间短暂地促进男性大脑性分化。 在子宫内的雌性动物组中，每侧0、1或2只雄性动物之间，未观察到全身雄激素含量的显著差异（连续雄性模型）或在尾侧有0、1或2只或更多雄性的雌性组中（宫颈侧），无论是否考虑胎仔第17-22天的合并数据或仅考虑胎仔第18和19天的数据。 这些结果没有提供雄性雄激素到达同一子宫角的雌性胎儿的证据。
The whole-body content of androgen (testosterone + 5-alpha-dihydrotestosterone) was significantly higher on Fetal Days 18 and 19 in male than in female rats; androgen content was equivalent in the two sexes at other fetal ages, including Days 16, 17, 20, and 21, and prior to parturition on Fetal Day 22. These results partially corroborate previous data of Weisz and Ward (Endocrinology 1980; 106:306-316), who measured testosterone in pooled plasma from rat fetuses and suggest that androgens contribute to masculine brain sexual differentiation only briefly during fetal life. No significant differences in whole-body androgen content were observed among groups of females situated in utero between 0, 1, or 2 males on each side (contiguous male model) or among groups of females with 0, 1, or 2 or more males located caudally (on the cervical side) in the same uterine horn, regardless of whether combined data from Fetal Days 17-22 or only Fetal Days 18 and 19 were considered. These results provide no evidence that androgens from males reach female fetuses in the same uterine horn.