Tic symptom profiles in subjects with Tourette syndrome from two genetically isolated populations
Tic symptom profiles in subjects with Tourette syndrome from two genetically isolated populations
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DOI：
10.1016/j.biopsych.2006.02.009
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发表时间：
2007-02-01
影响因子：
10.6
通讯作者：
Reus, Victor I.
中科院分区：
文献类型：
--
作者：
Mathews, Carol A.;Jang, Kerry L.;Reus, Victor I.
背景：抽动秽语综合征（TS）具有复杂的病因和广泛的表型表达变异性。方法：在1996年至2001年期间，收集了哥斯达黎加中央山谷121名TS患者和美国阿什肯纳兹犹太人（AS）人群133名TS患者的终生抽动和相关症状数据。采用聚类分层聚类分析，根据抽动症状对受试者进行分组。检测集群成员与可用辅助信息（发病年龄、抽动严重程度、合并症、药物治疗和家族史）的关联。结果：聚类分析在每个样本中确定了两个不同的组，主要是单纯性抽搐（聚类1）和多重复杂抽搐（聚类2）。集群2的成员与两个样本中抽动严重程度增加、整体损害、药物治疗和共病强迫症的存在相关，并且与抽动家族史、较低的语言智商、较早的发病年龄以及AS样本中共病强迫症和注意缺陷/多动障碍相关。结论：本研究在两个独立的TS研究样本中为一致和可重复的症状概况提供了证据。这些发现对TS的病因学研究具有启示意义。
Background: Tourette syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS.Methods: Lifetime tic and related symptom data were collected between 1996 and 2001 in 121 TS subjects from the Central Valley of Costa Rica and 133 TS subjects from the Ashkenazi Jewish (AS) population in the US. Subjects were grouped by tic symptoms using an agglomerative hierarchical cluster analysis. Cluster membership was tested for association with available ancillary information (age of onset, tic severity, comorbid disorders, medication treatment and family history).Results: Cluster analysis identified two distinct groups in each sample, those with predominantly simple tics (Cluster 1), and those with multiple complex tics (cluster 2). Membership in cluster 2 was correlated with increased tic severity, global impairment, medication treatment, and presence of comorbid obsessive-compulsive symptoms in both samples, and with family history of tics, lower verbal IQ, earlier age of onset, and comorbid obsessive-compulsive disorder and attention-deficit/hyperactivity disorder in the AS sample.Conclusions: This study provides evidence for consistent and reproducible symptom profiles in two independent TS study samples. These findings have implications for etiological studies of TS.