Prevalence and risk factors for wheezing and allergic diseases in preschool children: A perspective from the Mediterranean coast of Turkey
Prevalence and risk factors for wheezing and allergic diseases in preschool children: A perspective from the Mediterranean coast of Turkey
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DOI：
10.1016/j.aller.2017.01.002
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发表时间：
2017-07-01
影响因子：
1.8
通讯作者：
Kuyucu, S.
中科院分区：
文献类型：
--
作者：
Bolat, E.;Arikoglu, T.;Kuyucu, S.
目的：本研究的目的是确定过敏性疾病的患病率和危险因素在学龄前儿童在地中海地区的Turkish.Methods最大的城市之一：研究人群包括396名学龄前儿童参加城市日托中心在梅尔辛。在第一阶段，采用了一个全面的标准化问卷，从国际儿童哮喘和过敏研究（ISAAC）修改。在第二阶段，对45例频繁喘息和28例无喘息的儿童进行血清食物和吸入物特异性IgE和皮肤试验。曾有喘鸣、现有喘鸣、哮喘、过敏性鼻炎和湿疹的患病率分别为53%（210）、33.3%（132）、27.3%（108）、分别为13.4%（53）和8.3%（33）。遗传性过敏症的家族史（OR = 2.5，95% CI：1.34.7，p = 0.004），家中潮湿（OR = 2.4，95% CI：1.24.8，p = 0.008），肠道寄生虫病史（OR = 4.3，95% CI：1.710.9，p = 0.002），既往肺炎史（OR = 6.9，95%CI：1.925.9，p = 0.004），3个月前开始辅食（OR = 6.1，95%CI：1.426.9，p = 0.02）和食物过敏（OR = 3.1，95%CI：1.19.2，p = 0.03）是医生诊断的哮喘的重要危险因素。频繁喘息的危险因素是母亲在怀孕期间吸烟（OR = 5.2，95% CI：0.928.7，p = 0.05）和高血清IgE水平（OR = 2.9，95% CI：0.99.0，p = 0.05）。我们的研究是第一个在土耳其地中海地区学龄前儿童中进行的流行病学研究，证明了哮喘和过敏性疾病的高患病率，可能与潮湿的气候特性以及其他环境和遗传因素有关。(C)2017年SEICAP。出版社：Elsevier Espana，S.L.U. All rights reserved.
Objectives: The aim of the present study was to determine the prevalence and risk factors of allergic diseases in preschool children from one of the biggest cities in the Mediterranean Region of Turkey.Methods: The study population included 396 preschool children attending to urban daycare centres in Mersin. In the first stage, a comprehensive standardised questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC) was employed. In the second stage, serum food and inhalant specific IgE, and skin tests were performed in 45 children with frequent wheezing and 28 children with no wheezing.Results: The prevalence of ever wheezing, current wheezing, physician-diagnosed asthma, allergic rhinitis and eczema were 53% (210), 33.3% (132), 27.3% (108), 13.4% (53) and 8.3% (33), respectively. A family history of atopy (OR = 2.5, 95% CI: 1.34.7, p = 0.004), dampness at home (OR = 2.4, 95% CI: 1.24.8, p = 0.008), a history of intestinal parasites (OR = 4.3, 95% CI: 1.710.9, p = 0.002), previous history of pneumonia (OR = 6.9, 95% CI: 1.925.9, p = 0.004), initiation of complementary foods before the age of three months (OR = 6.1, 95%CI: 1.426.9, p = 0.02) and presence of food allergy (OR = 3.1, 95% CI: 1.19.2, p = 0.03) were found to be significant risk factors for physician-diagnosed asthma. The risk factors for frequent wheezing were maternal smoking during pregnancy (OR = 5.2, 95% CI: 0.928.7, p = 0.05) and high serum IgE levels (OR = 2.9, 95% CI: 0.99.0, p = 0.05) at borderline significance.Conclusion: Our study was the first epidemiological study in preschool children in the Mediterranean region of Turkey and demonstrated a high prevalence of asthma and allergic diseases, probably related to humid climatic properties in addition to other environmental and genetic factors. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.