Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004
Global and regional distribution of HIV-1 genetic subtypes and recombinants in 2004
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DOI：
10.1097/01.aids.0000247564.73009.bc
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发表时间：
2006-10-24
期刊：
影响因子：
3.8
通讯作者：
Osmanov, Saladin
中科院分区：
文献类型：
--
作者：
Hemelaar, Joris;Gouws, Eleanor;Osmanov, Saladin
目的：估计2004年HIV-1亚型和重组体的全球和区域分布。设计：进行了一项研究，其中将单个国家HIV-1亚型分布的分子流行病学数据与特定国家HIV感染者人数的估计相结合。收集了来自70个国家的23874份HIV-1样本的HIV-1亚型数据，这些样本占2004年全球所有HIV感染者的89%。由于在每个国家检测到的各种亚型的HIV-1感染的比例结合在各自国家的HIV感染者的数量，以产生区域和全球HIV-1亚型分布estimates.Results：亚型C占50%的全球所有感染在2004年。A、B、D、G亚型分别占12%、10%、3%、6%。F、H、J和K亚型共占感染的0.94%。循环重组形式CRF01_AE和CRF02_AG各占5%的病例，CRF03_AB占0.1%。其他重组体占其余8%的感染。所有的重组形式一起负责18%的感染worldwide.Conclusion：结合数据HIV-1亚型分布在个别国家与特定国家的艾滋病病毒感染者的人数估计提供了一个很好的方法，以产生估计的全球和区域HIV-1的遗传多样性在2004年。这些结果可以作为艾滋病毒科学家、公共卫生官员和艾滋病毒疫苗开发人员的重要资源。
Objective: To estimate the global and regional distribution of HIV-1 subtypes and recombinants in 2004.Design: A study was conducted in which molecular epidemiological data on HIV-1 subtype distribution in individual countries were combined with country-specific estimates of the number of people living with HIV.Methods: HIV-1 subtype data were collected for 23 874 HIV-1 samples from 70 countries, which together accounted for 89% of all people living with HIV worldwide in 2004. The proportions of HIV-1 infections due to various subtypes detected in each country were combined with the number of HIV infected people in the respective countries to generate regional and global HIV-1 subtype distribution estimates.Results: Subtype C accounted for 50% of all infections worldwide in 2004. Subtypes A, B, D and G accounted for 12%, 10%, 3% and 6%, respectively. The subtypes F, H, J and K together accounted for 0.94% of infections. The circulating recombinant forms CRF01_AE and CRF02_AG each were responsible for 5% of cases, and CRF03_AB for 0.1%. Other recombinants accounted for the remaining 8% of infections. All recombinant forms taken together were responsible for 18% of infections worldwide.Conclusion: Combining data on HIV-1 subtype distribution in individual countries with country-specific estimates of the number of people living with HIV provided a good method to generate estimates of the global and regional HIV-1 genetic diversity in 2004. The results could serve as an important resource for HIV scientists, public health officials and HIV vaccine developers.